desloratadine vs fluoxetine
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Side-by-side comparison of desloratadine and fluoxetine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
[ See Clinical Pharmacology (12.3) .] 7.2 Fluoxetine In controlled clinical studies co-administration of desloratadine with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
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Desloratadine is an antihistamine medicine. It helps relieve allergy symptoms.
Fluoxetine is a medicine that can help treat depression and other mental health conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
This medicine treats allergy symptoms. It can help with seasonal allergies like hay fever. It also treats year-round allergies and chronic hives by reducing itching and the number and size of hives.
Fluoxetine can treat major depressive disorder in adults and children. It also treats obsessive-compulsive disorder (OCD) in adults and children. Fluoxetine can help with bulimia nervosa (an eating disorder) and panic disorder. Sometimes, it is used with another medicine called olanzapine to treat depression related to bipolar disorder.
Desloratadine blocks histamine in your body. Histamine is a substance that causes allergy symptoms. By blocking histamine, this medicine reduces those symptoms.
Fluoxetine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluoxetine can help improve mood and reduce symptoms of depression, OCD, and other conditions.
- • Sore throat
- • Dry mouth
- • Muscle pain
- • Tiredness
- • Sleepiness
- • Abnormal dreams
- • Problems ejaculating
- • Loss of appetite
- • Feeling anxious
- • Feeling weak
- Fatigue 601
- Nausea 582
- Dyspnoea 532
- Headache 465
- Diarrhoea 448
- Drug Interaction 3,335
- Toxicity To Various Agents 3,316
- Nausea 3,233
- Fatigue 3,156
- Completed Suicide 2,904
Stop taking this medicine and get medical help right away if you have an allergic reaction. Signs of a reaction include rash, itching, hives, swelling, trouble breathing, or anaphylaxis.
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior. Fluoxetine is not approved for use in children younger than 7 years old.
Not enough studies have been done to know if desloratadine is safe during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if desloratadine passes into breast milk.
Talk to your doctor if you are pregnant or plan to become pregnant. Fluoxetine should only be used during pregnancy if the benefit outweighs the risk to the baby. Breastfeeding is not recommended while taking fluoxetine.
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How to Read This desloratadine vs fluoxetine Comparison
desloratadine is classified in the Second-Generation Antihistamine drug class, while fluoxetine sits within the Selective Serotonin Reuptake Inhibitor (SSRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, desloratadine has 2,628 submissions while fluoxetine has 15,944. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluoxetine slows down how your body breaks down desloratadine, which leads to higher levels of the allergy medicine in your blood. however, these higher levels are not known to cause any extra safety problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for desloratadine or fluoxetine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.