darifenacin vs digoxin
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of darifenacin and digoxin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.7 Digoxin Darifenacin (30 mg daily) did not have a clinically relevant effect on the pharmacokinetics of digoxin (0.25 mg) at steady-state. Routine therapeutic drug monitoring for digoxin should be continued [see Clinical Pharmacology (12.3) ] .
Enablex
Lanoxin
Darifenacin (Enablex) is a medicine that helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom so often.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
This medicine treats overactive bladder. If you have overactive bladder, you may feel a sudden need to urinate. You may also urinate more often than normal, or leak urine.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Darifenacin blocks certain receptors in the bladder. These receptors cause the bladder muscles to contract. By blocking them, the medicine helps the bladder relax and hold more urine.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
- • Dry mouth
- • Constipation
- • Headache
- • Upset stomach
- • Nausea
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- Peripheral Swelling 91
- Herpes Zoster 83
- Pneumonia Viral 79
- Anaemia 59
- Arthralgia 59
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
If you have bladder problems that cause you to have trouble urinating, use darifenacin with caution because it could make it harder to urinate. Use caution if you have stomach or bowel blockage, as this medicine can make it worse. Darifenacin may cause sleepiness, so do not drive or operate heavy machinery until you know how it affects you. Angioedema (swelling of the face, lips, tongue, and/or throat) has been reported with darifenacin and can be life-threatening.
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if darifenacin will harm your unborn baby. Talk to your doctor if you are breastfeeding or plan to breastfeed, as it is not known if darifenacin passes into breast milk.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
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How to Read This darifenacin vs digoxin Comparison
darifenacin is classified in the Anticholinergic (Overactive Bladder) drug class, while digoxin sits within the Cardiac Glycoside class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darifenacin has 371 submissions while digoxin has 23,407. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to darifenacin does not have a meaningful effect on the amount of digoxin that stays in your bloodstream.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for darifenacin or digoxin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.