cyclosporine vs verapamil
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Side-by-side comparison of cyclosporine and verapamil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Cyclosporine: Verapamil therapy may increase serum levels of cyclosporine.
Neoral, Sandimmune, Restasis
Calan, Verelan
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Verapamil is a drug that helps to lower blood pressure and treat chest pain (angina) and irregular heartbeats (arrhythmias). It works by relaxing blood vessels and slowing down the heart rate.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Verapamil is used to treat chest pain called angina. This includes angina that happens when you are resting or during normal activity. It is also used to control your heart rate if you have a fast or irregular heartbeat, such as atrial fibrillation or atrial flutter. Verapamil also treats high blood pressure.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
Verapamil belongs to a class of drugs called calcium channel blockers. It works by blocking calcium from entering heart and blood vessel cells. This relaxes and widens blood vessels, which lowers blood pressure and makes it easier for the heart to pump.
- • Irritation where the drops are applied (8%)
- • Constipation
- • Shortness of breath
- • Dizziness
- • Slow heart rate (less than 50 beats per minute)
- • Nausea
- Eye Irritation 7,786
- Pyrexia 4,064
- Eye Pain 3,808
- Nausea 3,623
- Diarrhoea 3,562
- Dyspnoea 356
- Nausea 341
- Drug Interaction 316
- Dizziness 286
- Hypotension 280
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
You should not take this medicine if you have severe heart problems, very low blood pressure, or certain types of irregular heartbeats without a pacemaker. Talk to your doctor if you have any of these conditions.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if verapamil will harm your unborn baby. Verapamil can pass into breast milk, so talk to your doctor about the best way to feed your baby if you take this medicine.
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How to Read This cyclosporine vs verapamil Comparison
cyclosporine is classified in the Calcineurin Inhibitor (Immunosuppressant) drug class, while verapamil sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclosporine has 22,843 submissions while verapamil has 1,579. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to verapamil can cause the amount of cyclosporine in your blood to rise to higher levels than normal.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cyclosporine or verapamil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.