citalopram vs warfarin
Side-by-side comparison of citalopram and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
For patients taking warfarin, carefully monitor the international normalized ratio [see Warning and Precautions (5.4) ].
Recommendation: Your doctor should closely monitor your blood clotting levels, also known as the INR, while you are taking both of these medications.
Celexa
Coumadin, Jantoven
Citalopram is a medicine used to treat depression in adults. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
Citalopram is used to treat major depressive disorder (MDD) in adults. Depression can cause feelings of sadness, loss of interest, and difficulty functioning in daily life. This medicine can help improve your mood and overall well-being.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Citalopram works by increasing the amount of serotonin in the brain. Serotonin is a chemical messenger that helps regulate mood. By blocking the reabsorption of serotonin, citalopram helps to improve communication between nerve cells and stabilize mood.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Ejaculation disorder (mostly delayed ejaculation)
- • Bleeding from any tissue or organ
- Tiredness 8,930
- Feeling sick to your stomach 8,204
- Head pain 6,654
- Loose stools 6,214
- Discomfort 5,899
- INR increased 10,275
- Shortness of breath 8,408
- Interaction with another medicine 6,289
- Tiredness 6,141
- Feeling sick to your stomach 5,921
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor will monitor you closely for worsening depression or suicidal thoughts. Citalopram is not approved for use in children.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
Taking citalopram late in pregnancy may cause problems for the newborn. Talk to your doctor about the risks and benefits of taking this medicine while pregnant. There is a pregnancy registry to monitor outcomes, call 1-844-405-6185 to register.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
Also Compare, Nearby Drugs
Compare citalopram with
How to Read This citalopram vs warfarin Comparison
citalopram is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, citalopram has 35,901 submissions while warfarin has 37,034. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to citalopram can change how warfarin works in your body, which may affect how quickly your blood is able to clot.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between citalopram and warfarin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.