cimetidine vs dutasteride/tamsulosin
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of cimetidine and dutasteride/tamsulosin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Cimetidine : Treatment with cimetidine resulted in a moderate increase in tamsulosin hydrochloride AUC (44%) [see Warnings and Precautions ( 5.2 ), Clinical Pharmacology ( 12.3 ) ] .
Tagamet
Jalyn
Cimetidine (Tagamet) reduces stomach acid. It is used to treat ulcers, heartburn, and other conditions where too much acid is produced.
This medicine combines two drugs to treat enlarged prostate in men. It helps improve urine flow and reduce symptoms.
Cimetidine treats active duodenal ulcers for short periods. It can also be used long-term at a lower dose to prevent ulcers from returning. This medicine also treats active benign gastric ulcers for a short time. Additionally, it can help with erosive gastroesophageal reflux disease (GERD), which damages the esophagus.
This medicine treats benign prostatic hyperplasia (BPH), also known as enlarged prostate, in men. It helps to relieve symptoms like frequent urination, difficulty starting urination, and weak urine stream. This medicine is not approved to prevent prostate cancer.
Cimetidine is an H2 receptor antagonist. This means it blocks histamine from attaching to certain cells in your stomach. By blocking histamine, cimetidine reduces the amount of acid your stomach makes.
This medicine contains two drugs that work in different ways. Dutasteride lowers a hormone called DHT that causes the prostate to grow. Tamsulosin relaxes the muscles in the prostate and bladder, making it easier to urinate.
- • Headache
- • Dizziness
- • Diarrhea
- • Problems with ejaculation
- • Impotence (trouble getting or keeping an erection)
- • Decreased sex drive
- • Dizziness
- • Breast enlargement or tenderness
- Chronic Kidney Disease 1,264
- Acute Kidney Injury 710
- Renal Failure 694
- Nausea 681
- Fatigue 598
- Shortness of breath 1,233
- Tiredness 1,142
- Feeling lightheaded or unsteady 986
- Weakness 933
- Loose stools 897
Reversible confusional states (like mental confusion, agitation, or hallucinations) have been reported, mostly in severely ill patients. These usually appear within 2-3 days of starting treatment and clear up within 3-4 days of stopping the drug.
This medicine can cause dizziness, lightheadedness, and fainting, especially when you stand up. Be careful to avoid falls or injuries. Do not take this medicine with other alpha-blockers, as it can lower your blood pressure too much. This medicine can affect your PSA levels, which are used to screen for prostate cancer, so tell your doctor you are taking this medicine. Pregnant women should not handle this medicine, as it can harm a male fetus.
Tell your doctor if you are pregnant or plan to become pregnant. The effects of cimetidine during pregnancy are not fully known. Talk to your doctor about the risks and benefits of taking cimetidine while breastfeeding.
This medicine is not for women. It can harm a male fetus if a pregnant woman is exposed to it. Pregnant women should not handle this medicine.
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How to Read This cimetidine vs dutasteride/tamsulosin Comparison
cimetidine is classified in the H2 Receptor Antagonist drug class, while dutasteride/tamsulosin sits within the 5-ARI / Alpha-Blocker Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cimetidine has 3,947 submissions while dutasteride/tamsulosin has 5,191. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to cimetidine can slow down how the body gets rid of tamsulosin, which leads to higher levels of the drug in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cimetidine or dutasteride/tamsulosin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.