Two medicines, side by side
Cetirizine vs methylprednisolone
Cetirizine and methylprednisolone are both labeled for allergies. Drugs@FDA records approvals of cetirizine since 1995 and of methylprednisolone since 1957. Pharmacies paid $0.0613 per cetirizine HCl 10 mg tablet and $0.121 per methylprednisolone 4 mg tablet (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like. Cetirizine's other strengths are brand-only: $7.35 per unit (Zerviate 0.24% eye drop). Methylprednisolone's other strengths are brand-only: $6.28 per Solu-medrol 40 mg vial. In FDA's classes, cetirizine is a histamine-1 receptor antagonist and methylprednisolone a corticosteroid.
Check it at the source: the cetirizine FDA label on DailyMed (effective August 7, 2026); the methylprednisolone FDA label on DailyMed (effective June 22, 2026).
Highlights of the cetirizine record
Cetirizine (All) · label of August 7, 2026
Used for
From the label: indicationstemporarily relieves these symptoms due to hay fever or other upper respiratory allergies: • runny nose, • sneezing, • itchy, watery eyes, • itching of the nose or throat
On the market
- Earliest approval on file
- December 8, 1995
- Generic labelers
- 149 labelers
- Pharmacy cost
- $0.0613 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 19
Highlights of the methylprednisolone record
Methylprednisolone (Solu-Medrol) · label of June 22, 2026
Used for
From the label: indicationsMethylprednisolone tablets are indicated in the following conditions: 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance). […]
On the market
- Earliest approval on file
- October 24, 1957
- Generic labelers
- 35 labelers
- Pharmacy cost
- $0.121 per tablet
Supply and safety
- Shortage
- In shortage
- Recalls
- 46
Source: FDA drug labels via openFDA (Cetirizine label of August 7, 2026, Methylprednisolone label of June 22, 2026); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do cetirizine and methylprednisolone differ on the record?
In FDA's classes, cetirizine is a histamine-1 receptor antagonist and methylprednisolone a corticosteroid.
Generics: cetirizine since 2007; methylprednisolone since 1978 (Drugs@FDA).
| Cetirizine | Methylprednisolone | |
|---|---|---|
| Labeled for | Allergies | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Pharmacologic class | Histamine-1 Receptor Antagonist | Corticosteroid |
| How it works (label) | n/a | n/a |
| Half-life (label) | n/a | n/a |
| Earliest approval on file (Drugs@FDA) | December 8, 1995 | October 24, 1957 |
| First generic approved | December 27, 2007 | March 28, 1978 |
| Generic labelers (NDC) | 149 labelers | 35 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.0613 per tablet (Cetirizine HCl 10 mg tablet) | $0.121 per tablet (Methylprednisolone 4 mg tablet) |
| 12-month price change | -11% | -22% |
| Boxed warning | No | No |
| Shortage now | No current entry | In shortage |
| Recalls recorded | 19 | 46 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 171,713 | 170,232 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to cetirizine
- every medicine labeled for the same conditions