celecoxib vs digoxin
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of celecoxib and digoxin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Digoxin Clinical Impact: The concomitant use of Celecoxib with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Intervention: During concomitant use of celecoxib and digoxin, monitor serum digoxin levels. ( 7 ) Digoxin : Concomitant use with celecoxib can increase serum concentration and prolong half-life of digoxin.
Celecoxib (Celebrex) is a medicine that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Celecoxib treats the symptoms of osteoarthritis and rheumatoid arthritis. It can also help with juvenile rheumatoid arthritis in children 2 years and older. Additionally, it is used for ankylosing spondylitis, acute pain, and menstrual pain.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Celecoxib blocks a substance in the body that causes pain and swelling. It targets COX-2, an enzyme involved in inflammation. By blocking COX-2, celecoxib reduces inflammation and relieves pain.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
- • Abdominal pain
- • Diarrhea
- • Upset stomach
- • Gas
- • Swelling in your legs or feet
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- Pain 12,294
- Arthralgia 10,923
- Fatigue 9,710
- Nausea 9,389
- Drug Hypersensitivity 7,713
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
Celecoxib may increase your risk of serious heart problems like heart attack and stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take celecoxib if you are having heart bypass surgery. Celecoxib can also increase the risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. The elderly and those with a history of ulcers or GI bleeding are at higher risk.
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Using celecoxib after about 20 weeks of pregnancy can cause kidney problems in the baby and low amniotic fluid. Avoid using celecoxib after 30 weeks of pregnancy because it can cause the baby's heart to close too early. If you are trying to get pregnant, talk to your doctor, as celecoxib may affect fertility.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
How to Read This celecoxib vs digoxin Comparison
celecoxib is classified in the COX-2 Selective NSAID drug class, while digoxin sits within the Cardiac Glycoside class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, celecoxib has 50,029 submissions while digoxin has 23,407. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking these drugs together can cause digoxin to stay in your system longer and reach higher levels in your bloodstream.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for celecoxib or digoxin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.