caspofungin vs cyclosporine
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of caspofungin and cyclosporine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS Cyclosporine : In two adult clinical studies, cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses) increased the AUC of caspofungin. Caspofungin did not increase the plasma levels of cyclosporine. There were transient increases in liver ALT and AST when caspofungin and cyclosporine were co-administered.
Cancidas
Neoral, Sandimmune, Restasis
Caspofungin is an antifungal medicine. It fights fungal infections in your body.
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Caspofungin treats several types of fungal infections. It is used for presumed fungal infections in patients with fever and low white blood cell counts. Caspofungin also treats infections caused by Candida, such as infections in the blood, abdomen, and esophagus. It can also treat invasive aspergillosis when other medicines don't work or can't be tolerated.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Caspofungin stops fungi from growing. It does this by blocking a key part of the fungal cell wall. This causes the fungal cells to die.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
- • Diarrhea
- • Fever
- • Increased liver enzyme levels
- • Decreased potassium levels
- • Rash
- • Irritation where the drops are applied (8%)
- Death 223
- Lung infection 200
- Fever 196
- Blood infection 193
- Severe blood infection leading to organ damage 175
- Eye Irritation 7,786
- Pyrexia 4,064
- Eye Pain 3,808
- Nausea 3,623
- Diarrhoea 3,562
Caspofungin can cause serious allergic reactions, including anaphylaxis. If you have signs of an allergic reaction, stop taking caspofungin right away. Caspofungin can also affect your liver. Your doctor will monitor your liver function with blood tests.
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
Caspofungin may harm your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if caspofungin passes into breast milk, so talk to your doctor about breastfeeding while taking this medicine.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
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How to Read This caspofungin vs cyclosporine Comparison
caspofungin is classified in the Echinocandin Antifungal drug class, while cyclosporine sits within the Calcineurin Inhibitor (Immunosuppressant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, caspofungin has 987 submissions while cyclosporine has 22,843. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to cyclosporine increases the levels of caspofungin in your blood and may cause temporary stress or irritation to your liver.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for caspofungin or cyclosporine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.