carbidopa/levodopa vs warfarin
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Side-by-side comparison of carbidopa/levodopa and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7 DRUG INTERACTIONS Drugs metabolized by COMT: use with caution ( 5.10 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of carbidopa, levodopa and...
Sinemet
Coumadin, Jantoven
This medicine contains carbidopa, levodopa, and entacapone. It is used to treat Parkinson's disease.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
This medicine treats Parkinson's disease. It can help when other medicines stop working as well near the end of a dose. It can also replace other medicines containing similar ingredients.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Levodopa turns into dopamine in your brain, helping to control movement. Carbidopa helps levodopa get to your brain. Entacapone helps levodopa work longer.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Uncontrolled movements
- • Diarrhea
- • Nausea
- • Belly pain
- • Vomiting
- • Bleeding from any tissue or organ
- Fall 4,293
- Seeing or hearing things that are not there 3,733
- Shaking 3,257
- Uncontrolled movements 2,903
- Death 2,727
- International Normalised Ratio Increased 10,276
- Dyspnoea 8,408
- Drug Interaction 6,288
- Fatigue 6,143
- Nausea 5,921
This medicine can make you fall asleep suddenly, even when you feel awake. Be careful when driving or doing other activities where you need to be alert. Stopping this medicine suddenly can cause serious problems like fever and confusion.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
This medicine may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine passes into breast milk.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
How to Read This carbidopa/levodopa vs warfarin Comparison
carbidopa/levodopa is classified in the Dopamine Precursor Combination drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, carbidopa/levodopa has 16,913 submissions while warfarin has 37,036. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to these drugs can interfere with how your body breaks down certain medicines, which may change how well your blood thinner works.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for carbidopa/levodopa or warfarin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.