Two medicines, side by side
Candesartan vs metoprolol
Candesartan and metoprolol are both labeled for high blood pressure and heart failure. Drugs@FDA records approvals of candesartan since 1998 and of metoprolol since 1978. Pharmacies paid $0.478 per candesartan cilexetil 16 mg tablet and $0.085 per metoprolol succ ER 100 mg tablet (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like. Metoprolol's other strengths are brand-only: $1.20 per mL (Lopressor 10 mg/mL oral solution). In FDA's classes, candesartan is an angiotensin 2 receptor blocker and metoprolol a beta-adrenergic blocker.
Check it at the source: the candesartan FDA label on DailyMed (effective January 15, 2026); the metoprolol FDA label on DailyMed (effective March 3, 2026).
Highlights of the candesartan record
Candesartan (Atacand) · label of January 15, 2026
FETAL TOXICITY When pregnancy is detected, discontinue candesartan cilexetil as soon as possible [see Warnings and Precautions ( 5.1 ) and Use in Specific Populations ( 8.1 )]. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus [see Warnings and Precautions ( 5.1 ) and Use in Specific Populations ( 8.1 )]. WARNING: FETAL TOXICITY See full prescribing information for complete boxed warning.
Used for
From the label: indicationsCandesartan cilexetil is an angiotensin II receptor blocker (ARB) indicated for: Treatment of hypertension in adults and children 1 to < 17 years of age, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions (1.1). […]
On the market
- Earliest approval on file
- June 4, 1998
- Generic labelers
- 8 labelers
- Pharmacy cost
- $0.478 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 9
Highlights of the metoprolol record
Metoprolol (Lopressor) · label of March 3, 2026
Used for
From the label: indicationsTOPROL-XL, metoprolol succinate, is a beta-adrenergic blocker indicated for the treatment of: Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. ( 1.1 ) Angina Pectoris. […]
On the market
- Earliest approval on file
- August 7, 1978
- Generic labelers
- 74 labelers
- Pharmacy cost
- $0.085 per tablet
Supply and safety
- Shortage
- A presentation being discontinued
- Recalls
- 39
Source: FDA drug labels via openFDA (Candesartan label of January 15, 2026, Metoprolol label of March 3, 2026); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do candesartan and metoprolol differ on the record?
In FDA's classes, candesartan is an angiotensin 2 receptor blocker and metoprolol a beta-adrenergic blocker.
How each works, in its label's words: Candesartan, “Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II).”; Metoprolol, “Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocking agent.”
Half-life, in each label's words: Candesartan, “The elimination half-life of candesartan is approximately 9 hours.”; Metoprolol, “Elimination Elimination is mainly by biotransformation in the liver, and the plasma half-life ranges from approximately …”
Only the candesartan label carries a boxed warning.
Generics: candesartan since 2013; metoprolol since 1993 (Drugs@FDA).
| Candesartan | Metoprolol | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease |
| Pharmacologic class | Angiotensin 2 Receptor Blocker | beta-Adrenergic Blocker |
| How it works (label) | Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). | Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocking agent. |
| Half-life (label) | The elimination half-life of candesartan is approximately 9 hours. | Elimination Elimination is mainly by biotransformation in the liver, and the plasma half-life ranges from approximately 3 to 7 hours. |
| Earliest approval on file (Drugs@FDA) | June 4, 1998 | August 7, 1978 |
| First generic approved | May 3, 2013 | December 21, 1993 |
| Generic labelers (NDC) | 8 labelers | 74 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.478 per tablet (Candesartan cilexetil 16 mg tablet) | $0.085 per tablet (Metoprolol succ ER 100 mg tablet) |
| 12-month price change | -15% | -8% |
| Boxed warning | Yes | No |
| Shortage now | No current entry | A presentation being discontinued |
| Recalls recorded | 9 | 39 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 60,889 | 353,609 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to candesartan
- every medicine labeled for the same conditions