Two medicines, side by side
Calcium carbonate vs bismuth subsalicylate
Calcium carbonate and bismuth subsalicylate are both labeled for acid reflux and ulcers. Pharmacies paid $0.0315 per tablet (Antacid ex-str 750 mg tablet chewable) and $0.0817 per tablet (Bismuth 262 mg tablet chewable) (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like.
Check it at the source: the calcium carbonate FDA label on DailyMed (effective December 5, 2024); the bismuth subsalicylate FDA label on DailyMed (effective October 3, 2023).
Highlights of the calcium carbonate record
Calcium carbonate · label of December 5, 2024
Used for
From the label: indicationsrelieves • heartburn • acid indigestion • sour stomach • upset stomach associated with these symptoms
On the market
- Earliest approval on file
- n/a
- Generic labelers
- none listed
- Pharmacy cost
- $0.0315 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 1
Highlights of the bismuth subsalicylate record
Bismuth subsalicylate · label of October 3, 2023
Used for
From the label: indicationsrelieves travelers' diarrhea diarrhea upset stomach due to overindulgence in food and drink, including: heartburn indigestion nausea gas belching fullness
On the market
- Earliest approval on file
- n/a
- Generic labelers
- none listed
- Pharmacy cost
- $0.0817 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 1
Source: FDA drug labels via openFDA (Calcium carbonate label of December 5, 2024, Bismuth subsalicylate label of October 3, 2023); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do calcium carbonate and bismuth subsalicylate differ on the record?
| Calcium carbonate | Bismuth subsalicylate | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Diarrhea, Acid reflux and ulcers, Nausea and vomiting |
| Pharmacologic class | n/a | n/a |
| How it works (label) | n/a | n/a |
| Half-life (label) | n/a | n/a |
| Earliest approval on file (Drugs@FDA) | n/a | n/a |
| First generic approved | none | none |
| Generic labelers (NDC) | none listed | none listed |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.0315 per tablet (Antacid ex-str 750 mg tablet chewable) | $0.0817 per tablet (Bismuth 262 mg tablet chewable) |
| 12-month price change | -0.8% | -2% |
| Boxed warning | No | No |
| Shortage now | No current entry | No current entry |
| Recalls recorded | 1 | 1 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 66,848 | 5,773 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to calcium carbonate
- every medicine labeled for the same conditions