baclofen vs chlorzoxazone
Side-by-side comparison of baclofen and chlorzoxazone Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Lioresal, Gablofen
Parafon Forte
Baclofen is a muscle relaxant. It helps to relieve muscle spasms and stiffness.
Chlorzoxazone is a muscle relaxant. It helps to relieve discomfort from painful muscle problems.
Baclofen is used to treat muscle spasticity (stiffness) caused by multiple sclerosis. It can help with muscle spasms, pain, and rigidity. It may also help people with spinal cord injuries or diseases. Baclofen is not for muscle spasms caused by arthritis or other rheumatic problems.
This medicine treats discomfort from muscle problems. It is used with rest and physical therapy. It helps with acute, painful muscle and bone conditions.
Baclofen works by affecting the nerves in your spinal cord. It decreases the signals that cause your muscles to tighten. This helps to relieve muscle stiffness and spasms.
The way this drug works is not fully known. It may work by making you feel sleepy. This medicine does not directly relax your muscles.
- • Drowsiness
- • Dizziness
- • Weakness
- • Nausea
- • Drowsiness
- • Dizziness
- • Lightheadedness
- • Feeling unwell
- • Over-stimulation
- Tiredness 6,148
- Pain 5,657
- Medicine not working 5,452
- Fall 5,421
- Feeling sick to your stomach 4,595
- Feeling unsteady or lightheaded 94
- Feeling sick to your stomach 94
- Feeling very tired 92
- General discomfort 90
- Medicine not working 81
If you stop taking baclofen suddenly, you may experience withdrawal symptoms. Talk to your doctor before stopping this medication.
If you are intolerant to chlorzoxazone, you should not take this medicine.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if baclofen will harm your unborn baby. Baclofen can pass into breast milk.
Talk to your doctor if you are pregnant or breastfeeding. It is not known if this medicine will harm your unborn baby. It is also not known if this medicine passes into breast milk.
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How to Read This baclofen vs chlorzoxazone Comparison
baclofen is classified in the GABA-B Agonist (Muscle Relaxant) drug class, while chlorzoxazone sits within the Muscle Relaxant class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, baclofen has 27,273 submissions while chlorzoxazone has 451. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between baclofen and chlorzoxazone — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.