azithromycin vs digoxin
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Side-by-side comparison of azithromycin and digoxin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.3 Potential Drug-Drug Interaction with Macrolides Interactions with digoxin, colchicine or phenytoin have not been reported in clinical trials with azithromycin. Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised.
Zithromax, Z-Pack
Lanoxin
Azithromycin is an antibiotic that fights bacteria. It is used to treat many different types of infections.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Azithromycin treats mild to moderate infections caused by certain bacteria. In adults, it can treat bronchitis, sinus infections, skin infections, urethritis, cervicitis, and genital ulcers. In children over 6 months old, it can treat ear infections and pneumonia. It can also treat pharyngitis/tonsillitis in children 2 years and older.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Azithromycin belongs to a class of drugs called macrolide antibiotics. It works by stopping the growth of bacteria. This helps your body fight off the infection.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
- • Diarrhea (5-14%)
- • Nausea (3-18%)
- • Abdominal pain (3-7%)
- • Vomiting (2-7%)
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- Dyspnoea 3,059
- Nausea 2,232
- Pain 2,205
- Pneumonia 2,085
- Cough 2,031
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
This drug can cause serious allergic reactions, liver problems, and heart rhythm changes. Tell your doctor right away if you have signs of an allergic reaction, like rash or swelling. Also, tell your doctor if you have liver problems, heart problems, or muscle weakness.
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Studies haven't shown major risks to the baby during pregnancy. Talk to your doctor if you are pregnant or breastfeeding before taking this medicine.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Also Compare, Nearby Drugs
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How to Read This azithromycin vs digoxin Comparison
azithromycin is classified in the Macrolide Antibiotic drug class, while digoxin sits within the Cardiac Glycoside class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, azithromycin has 11,612 submissions while digoxin has 23,407. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to it is not yet fully known how these drugs interact, but azithromycin might change how your body handles digoxin.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for azithromycin or digoxin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.