amiodarone vs nateglinide
Side-by-side comparison of amiodarone and nateglinide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Table 2: Clinically Significant Drug Interactions with Nateglinide Drugs That May Increase the Blood-Glucose-Lowering Effect of Nateglinide and Susceptibility to Hypoglycemia Drugs: Nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, monoamine oxidase inhibitors, non-selective beta-adrenergic-blocking agents, anabolic hormones (e.g., methandrostenolone), guanethidine, gymnema sylvestre, glucomannan, thioctic acid, and inhibitors of CYP2C9 (e.g., amiodarone, fluconazole, voriconazole, sulfinpyrazone) or in patients known to be poor metabolizers of CYP2C9 substrates, alcohol.
Recommendation: You should monitor your blood sugar levels carefully and let your doctor know if you experience symptoms of low blood sugar.
Cordarone, Pacerone
Starlix
Amiodarone (Pacerone) is a medicine used to treat life-threatening, irregular heartbeats. It helps to restore a normal heart rhythm when other medicines don't work or can't be used.
Nateglinide (Starlix) helps control blood sugar in adults with type 2 diabetes. It should be used with diet and exercise.
This medicine treats very fast, irregular heartbeats in the ventricles (lower chambers of the heart). It is used when these irregular heartbeats are life-threatening. It is also used when other medicines don't work well enough or cause too many side effects. This medicine is for adults.
Nateglinide is used to help lower blood sugar in adults who have type 2 diabetes. You should also follow a diet and exercise plan while taking this medicine. Nateglinide should not be used if you have type 1 diabetes or diabetic ketoacidosis.
Amiodarone affects the electrical signals in your heart. It slows down these signals, which helps your heart beat normally. This medicine can help prevent dangerous, fast heart rhythms.
Nateglinide helps your pancreas release insulin after you eat. Insulin helps move sugar from your blood into your cells. This lowers your blood sugar levels after meals.
- • Low thyroid levels (hypothyroidism)
- • High thyroid levels (hyperthyroidism)
- • Heart failure
- • Irregular heartbeats
- • Problems with the heart's natural pacemaker (SA node dysfunction)
- • Upper respiratory infection
- • Back pain
- • Flu symptoms
- • Dizziness
- • Joint pain
- Difficulty breathing 1,158
- Weakness 975
- Tiredness 893
- Feeling sick to your stomach 605
- Coughing 597
- High blood sugar 76
- Diarrhea 63
- Difficulty breathing 62
- Tiredness 56
- Feeling sick to your stomach 54
This medicine can cause serious problems with your lungs, liver, and heart. Lung problems can be fatal. Your doctor will check your lungs with X-rays and breathing tests. Liver problems can also be fatal. Your doctor will check your liver with blood tests. This medicine can also make irregular heartbeats worse. You will likely start this medicine in the hospital where your heart can be monitored.
Nateglinide can cause low blood sugar (hypoglycemia). Take it before meals and skip the dose if you skip the meal to help prevent this. There have been no studies showing that nateglinide lowers your risk of heart or blood vessel problems.
This medicine can harm your unborn baby. It can cause thyroid problems, slow heart rate, and brain development issues. Do not breastfeed while taking this medicine.
It is not known if nateglinide can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Nateglinide is not recommended if you are breastfeeding because it may cause low blood sugar in the baby.
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How to Read This amiodarone vs nateglinide Comparison
amiodarone is classified in the Class III Antiarrhythmic drug class, while nateglinide sits within the Meglitinide class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amiodarone has 4,228 submissions while nateglinide has 311. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to amiodarone interferes with the way your body breaks down nateglinide. this can increase the effect of the medicine and lead to dangerously low blood sugar levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amiodarone and nateglinide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.