amiloride vs indomethacin
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Side-by-side comparison of amiloride and indomethacin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Since indomethacin and potassium-sparing diuretics, including amiloride HCl, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.
Midamor
Indocin
Amiloride is a water pill that helps your body hold onto potassium. It is often used with other water pills to prevent low potassium levels.
Indomethacin is a drug that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Amiloride treats high blood pressure and heart failure. It helps restore normal potassium levels if you develop low potassium while taking other water pills. It can also prevent low potassium if you are at risk, such as if you take digoxin or have heart rhythm problems. Amiloride is not usually prescribed alone.
Indomethacin treats moderate to severe rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It can also help with acute painful shoulder (bursitis or tendinitis) and gouty arthritis. This medicine reduces pain and swelling in your joints.
Amiloride blocks sodium channels in your kidneys. This action reduces the amount of potassium lost in your urine. This helps to maintain or increase potassium levels in your body.
Indomethacin works by blocking substances in the body that cause pain and inflammation. These substances are called prostaglandins. By blocking them, indomethacin helps to reduce swelling, pain, and stiffness.
- • Headache
- • Nausea
- • Loss of appetite
- • Diarrhea
- • Vomiting
- • Headache
- • Dizziness
- • Upset stomach
- • Nausea
- Dyspnoea 69
- Diarrhoea 57
- Nausea 49
- Vomiting 39
- Fatigue 37
- Fatigue 1,102
- Arthralgia 1,002
- Headache 990
- Pain 921
- Nausea 907
Amiloride can cause high potassium levels, which can be dangerous. You should not take this medicine if you already have high potassium, kidney problems, or are taking other potassium-sparing diuretics or potassium supplements. Your doctor should check your potassium levels regularly.
Indomethacin may increase your risk of serious heart problems like heart attack or stroke, which can be fatal. This risk may occur early in treatment and may increase with longer use. You should not take this medicine before or after heart bypass surgery (CABG). Indomethacin can also increase your risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. Elderly patients and those with a history of ulcers or GI bleeding are at higher risk.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if amiloride can harm an unborn baby or pass into breast milk.
Using indomethacin during the later stages of pregnancy may harm your unborn baby. Limit use between 20 and 30 weeks of pregnancy, and avoid use after 30 weeks. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This amiloride vs indomethacin Comparison
amiloride is classified in the Potassium-Sparing Diuretic drug class, while indomethacin sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amiloride has 251 submissions while indomethacin has 4,922. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these drugs can cause potassium levels in your blood to rise to unsafe levels and may affect how your kidneys work.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for amiloride or indomethacin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.