alogliptin vs linagliptin

PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.

Side-by-side comparison of alogliptin and linagliptin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

Drug Class
alogliptin DPP-4 Inhibitor
linagliptin DPP-4 Inhibitor
Type
alogliptin Prescription
linagliptin Prescription
Summary
alogliptin

No summary available.

linagliptin

No summary available.

What It Treats
alogliptin

Information not available.

linagliptin

Information not available.

How It Works
alogliptin

Information not available.

linagliptin

Information not available.

Common Side Effects
alogliptin
  • Upper respiratory tract infection
  • Common cold
  • Diarrhea
  • High blood pressure
  • Headache
linagliptin
  • Runny nose or sore throat
  • Diarrhea
FAERS Reports
alogliptin
  • Diarrhoea 134
  • Nausea 124
  • Vomiting 110
  • Acute Kidney Injury 101
  • Pemphigoid 101
linagliptin
  • Blood Glucose Increased 1,326
  • Diarrhoea 1,196
  • Nausea 1,138
  • Fatigue 1,028
  • Dyspnoea 998
Serious Warnings
alogliptin

No specific warnings noted.

linagliptin

No specific warnings noted.

Pregnancy
alogliptin

No pregnancy information available.

linagliptin

No pregnancy information available.

Also Compare, Nearby Drugs

How to Read This alogliptin vs linagliptin Comparison

alogliptin is classified in the DPP-4 Inhibitor drug class, while linagliptin sits within the DPP-4 Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, alogliptin has 570 submissions while linagliptin has 5,686. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for alogliptin or linagliptin.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.