allopurinol vs amoxicillin
Side-by-side comparison of allopurinol and amoxicillin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
( 7.1 ) Concomitant use of Amoxicillin and Clavulanate Potassium and oral anticoagulants may increase the prolongation of prothrombin time.( 7.2 ) Co-administration with allopurinol increases the risk of rash. 7.3 Allopurinol The concurrent administration of allopurinol and amoxicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving amoxicillin alone. It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
Recommendation: Watch for any signs of a skin rash and contact your healthcare provider immediately if one appears.
Zyloprim
Amoxil
Allopurinol is a medicine that lowers uric acid levels in your body. It helps prevent gout attacks and other problems caused by high uric acid.
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections. It contains amoxicillin, an antibiotic, and clavulanate, which helps the amoxicillin work better.
This medicine is used to manage gout in adults. Gout causes painful attacks, joint damage, and kidney problems. Allopurinol is also used in adults and children with leukemia, lymphoma, and solid tumors who are getting cancer treatment. It helps manage high uric acid caused by the cancer treatment. It can also help adults who get calcium oxalate kidney stones often.
This medicine treats infections like lower respiratory infections, ear infections (otitis media), sinus infections, skin infections, and urinary tract infections. It works against specific bacteria that cause these infections. However, it should only be used when tests show the bacteria are susceptible to it, to avoid antibiotic resistance.
Allopurinol works by blocking an enzyme called xanthine oxidase. This enzyme helps your body make uric acid. By blocking it, allopurinol reduces the amount of uric acid in your blood and urine.
Amoxicillin kills bacteria by stopping them from building cell walls. Some bacteria produce a substance called beta-lactamase, which can destroy amoxicillin. Clavulanate blocks beta-lactamase, allowing amoxicillin to effectively kill the bacteria.
- • Diarrhea
- • Nausea
- • Increased liver enzyme levels
- • Gout attacks
- • Skin rash
- • Diarrhea or loose stools
- • Nausea
- • Skin rashes
- • Hives
- • Vomiting
- Diarrhea 8,423
- Tiredness 7,965
- Difficulty breathing 7,659
- Feeling sick to your stomach 7,061
- Death 6,664
- Long-term kidney disease 4,661
- Sudden kidney damage 4,200
- Diarrhea 4,083
- Allergic reaction to the medicine 3,744
- Feeling sick to your stomach 3,700
Allopurinol can cause serious skin reactions that can be deadly. Stop taking this medicine and get medical help right away if you get a skin rash or any other signs of an allergic reaction.
This medicine can cause serious allergic reactions, including fatal ones. Stop taking it and get medical help right away if you have any signs of an allergic reaction. This medicine can also cause severe skin reactions. Tell your doctor if you develop a rash. It can also cause liver problems and severe diarrhea.
Allopurinol may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can pass into breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Amoxicillin passes into breast milk and may cause harm to a nursing infant. Talk to your doctor before breastfeeding.
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How to Read This allopurinol vs amoxicillin Comparison
allopurinol is classified in the Xanthine Oxidase Inhibitor drug class, while amoxicillin sits within the Penicillin Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, allopurinol has 37,772 submissions while amoxicillin has 20,388. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to taking these two medicines at the same time increases the chance that you will develop a skin rash. it is not fully known if the drugs themselves or the high uric acid levels in the body cause this reaction.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between allopurinol and amoxicillin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.