aliskiren vs valsartan
Side-by-side comparison of aliskiren and valsartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
7 DRUG INTERACTIONS Avoid concomitant use with aliskiren in patients with estimated glomerular filtration rate (eGFR) less than 60. The concomitant use of ENTRESTO with aliskiren is contraindicated in patients with diabetes [see Contraindications (4)] . Avoid use with aliskiren in patients with renal impairment (eGFR less than 60 mL/min/1.73 m 2 ).
Recommendation: Do not use these drugs together if you have diabetes or kidney disease. Your doctor will monitor your kidney health and blood pressure very closely if these are used together.
Tekturna is a medicine used to treat high blood pressure. It helps lower blood pressure, which can reduce the risk of strokes and heart attacks.
Entresto is a medicine that combines two drugs to help adults and children with heart failure. It can lower the risk of death and hospitalization.
Tekturna is used to treat high blood pressure in adults and children who weigh at least 110 pounds and are 6 years or older. Lowering your blood pressure helps prevent strokes and heart attacks. It is important to manage high blood pressure with a healthy lifestyle too.
Entresto is used to treat heart failure in adults and children aged one year and older. It helps people whose hearts don't pump blood well enough. It can reduce hospital visits and the risk of death from heart problems.
Tekturna works by blocking a substance in your body called renin. Renin helps to control your blood pressure. By blocking renin, Tekturna helps to lower your blood pressure.
Entresto works by blocking two substances in your body that can worsen heart failure. One substance is neprilysin, and the other is angiotensin II. By blocking these, Entresto helps your heart pump blood more easily and reduces strain.
- • Diarrhea
- • Low blood pressure
- • High potassium levels in your blood
- • Cough
- • Dizziness
- • Kidney problems
- Weakness 367
- Fall 356
- Feeling sick to your stomach 336
- Shortness of breath 314
- Headache 301
- Feeling tired 5,476
- Feeling lightheaded 5,251
- Difficulty breathing 5,251
- Feeling sick to your stomach 5,164
- Loose stools 4,581
Tekturna can harm your unborn baby, even causing death. If you become pregnant, stop taking Tekturna right away and tell your doctor.
Entresto can harm your unborn baby, even causing death. If you are pregnant or become pregnant, stop taking Entresto right away and tell your doctor.
Tekturna can cause serious harm or death to an unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor about other blood pressure medicines. Breastfeeding is not recommended while taking Tekturna.
Entresto can cause serious harm or death to an unborn baby. Do not take this medicine if you are pregnant. Breastfeeding is not recommended while taking Entresto.
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How to Read This aliskiren vs valsartan Comparison
aliskiren is classified in the Direct Renin Inhibitor drug class, while valsartan sits within the Angiotensin II Receptor Blocker (ARB) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aliskiren has 1,674 submissions while valsartan has 25,723. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to both drugs work on the same system in the body to control blood pressure, which can put too much stress on the kidneys. this is especially risky for people who have diabetes or existing kidney problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aliskiren and valsartan - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.