alfuzosin vs solifenacin
Side-by-side comparison of alfuzosin and solifenacin Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Uroxatral
Vesicare
Alfuzosin is a medicine that helps men with enlarged prostate glands. It relaxes the muscles in the prostate and bladder, making it easier to urinate.
Solifenacin (Vesicare) is a medicine that helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom so often.
This medicine treats the symptoms of benign prostatic hyperplasia (BPH), also known as an enlarged prostate. BPH can cause problems with urination, such as difficulty starting or stopping, frequent urination, and feeling like you can't empty your bladder. Alfuzosin helps to improve these symptoms.
This medicine treats overactive bladder in adults. It helps with symptoms like needing to urinate urgently, frequent urination, and leaking urine. It works to reduce these urges and help you control your bladder.
Alfuzosin belongs to a class of drugs called alpha-1 blockers. It works by relaxing the muscles in the prostate and bladder neck. This relaxation allows urine to flow more freely, relieving the symptoms of BPH.
Solifenacin blocks certain receptors in the bladder called muscarinic receptors. By blocking these receptors, the bladder muscle relaxes. This helps to reduce the urge to urinate frequently and reduces leakage.
- • Dizziness
- • Upper respiratory tract infection
- • Headache
- • Fatigue
- • Dry mouth
- • Constipation
- • Urinary tract infection
- • Blurred vision
- The medicine is not working 112
- Using the medicine for something it's not approved for 96
- Difficulty breathing 89
- The medicine is interacting with another medicine 87
- Tiredness 87
- Medicine not working 3,600
- Dry mouth 1,616
- Constipation 1,613
- Tiredness 1,275
- Using medicine for unapproved purpose 1,236
Alfuzosin can cause your blood pressure to drop suddenly when you stand up, leading to dizziness or fainting. Be careful when standing up quickly, especially when you first start taking this medicine. If you have chest pain (angina), tell your doctor immediately. This medicine may also affect your heart rhythm. Tell your doctor if you have a history of heart problems.
This medicine may cause swelling of the face, lips, tongue, or throat. If this happens, stop taking solifenacin and get medical help right away. This medicine is not recommended if you have a bladder problem that makes it hard to empty your bladder. It is also not recommended if you have slow movement in your stomach or intestines. This medicine may cause sleepiness, so be careful driving or operating heavy machinery until you know how it affects you.
This medicine is only for men and is not intended for use in women. It is not known if alfuzosin can harm an unborn baby or pass into breast milk.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if solifenacin can harm your unborn baby. It is also not known if solifenacin passes into breast milk.
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How to Read This alfuzosin vs solifenacin Comparison
alfuzosin is classified in the Alpha-1 Blocker (BPH) drug class, while solifenacin sits within the Anticholinergic (Overactive Bladder) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, alfuzosin has 471 submissions while solifenacin has 9,340. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between alfuzosin and solifenacin — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.