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adapalene vs mupirocin

Side-by-side comparison of adapalene and mupirocin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

Drug Class
adapalene Retinoid (Topical)
mupirocin Topical Antibiotic
Type
adapalene Over-the-Counter
mupirocin Prescription
Summary
adapalene

No summary available.

mupirocin

Mupirocin cream is a topical antibiotic. It is used to treat skin infections caused by certain bacteria.

What It Treats
adapalene

Information not available.

mupirocin

Mupirocin cream treats skin infections caused by Staphylococcus aureus and Streptococcus pyogenes bacteria. It is for use on skin injuries like cuts or scrapes that have become infected. The infected area should be no larger than 10 cm long or 100 cm squared.

How It Works
adapalene

Information not available.

mupirocin

Mupirocin stops bacteria from growing. It does this by blocking the bacteria's ability to make proteins. This helps to clear up the infection.

Common Side Effects
adapalene
  • Dry skin
  • Contact dermatitis (skin rash)
  • Burning feeling on the skin where you put the medicine
  • Skin irritation
mupirocin
  • Headache
  • Rash
  • Nausea
FAERS Reports
adapalene
  • Dry skin 44,990
  • Burning feeling on the skin 41,633
  • Acne 39,264
  • Redness 38,379
  • Skin irritation 26,225
mupirocin
  • Feeling sick to your stomach 882
  • Discomfort 877
  • Feeling tired 765
  • Eye problem causing vision loss 750
  • Pain in your head 712
Serious Warnings
adapalene

No specific warnings noted.

mupirocin

Rarely, severe allergic reactions can occur, including anaphylaxis, hives, swelling, and widespread rash. If you have diarrhea while using this medicine, tell your doctor right away. Long-term use may lead to new infections.

Pregnancy
adapalene

No pregnancy information available.

mupirocin

It is not known if mupirocin cream will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if mupirocin passes into breast milk, but it is not expected to be harmful.

Also Compare, Nearby Drugs

How to Read This adapalene vs mupirocin Comparison

adapalene is classified in the Retinoid (Topical) drug class, while mupirocin sits within the Topical Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, adapalene has 190,491 submissions while mupirocin has 3,986. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between adapalene and mupirocin - always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.