acetaminophen/oxycodone vs lamotrigine
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Side-by-side comparison of acetaminophen/oxycodone and lamotrigine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Lamotrigine Serum lamotrigine concentrations may be reduced, producing a decrease in therapeutic effects.
Percocet
Lamictal
Percocet is a strong pain medicine. It contains acetaminophen and oxycodone, an opioid.
Lamotrigine is a medicine that can treat seizures and bipolar disorder. It works by reducing irregular electrical activity in the brain.
Percocet is used to manage severe pain. It is for pain that requires an opioid medicine. You should only use Percocet if other pain treatments don't work well enough.
Lamotrigine can treat epilepsy in adults and children 2 years and older. It can help with partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome. It can also be used to delay mood episodes in adults with bipolar I disorder.
Oxycodone works in the brain to block pain signals. Acetaminophen also helps to reduce pain and fever. Together, they provide stronger pain relief.
Lamotrigine affects how nerves in the brain send signals to each other. It is thought to work by decreasing the release of certain chemicals. This helps to stabilize electrical activity and prevent seizures or mood swings.
- • Lightheadedness
- • Dizziness
- • Drowsiness
- • Nausea
- • Vomiting
- • Dizziness
- • Headache
- • Double vision
- • Uncoordinated movements
- • Nausea
- Tiredness 34,486
- Feeling sick to your stomach 29,571
- Head pain 28,378
- Aches 28,322
- Loose stools 23,628
- Rash 8,408
- Seizure 6,527
- Nausea 6,149
- Fatigue 5,915
- Dizziness 5,770
Percocet has a boxed warning. It can cause addiction, abuse, and misuse, leading to overdose and death. It can also cause life-threatening breathing problems, especially when starting or increasing the dose. Accidental ingestion, even one dose, can cause a fatal overdose, especially in children. Taking Percocet with benzodiazepines or other CNS depressants, including alcohol, can cause severe sedation, breathing problems, coma, and death. Using opioids for a long time during pregnancy can cause withdrawal symptoms in the newborn. Acetaminophen can cause liver damage if you take too much.
Lamotrigine can cause a serious skin rash that may require you to go to the hospital. This rash can be life-threatening. The risk is higher in children. Stop taking lamotrigine and see a doctor right away if you get a rash, fever, or swollen lymph nodes.
Taking Percocet for a long time during pregnancy can cause withdrawal symptoms in the baby after birth. Make sure a newborn specialist is available when you deliver your baby.
Tell your doctor if you are pregnant or plan to become pregnant. Lamotrigine may cause harm to an unborn baby. There is a pregnancy registry for women who take lamotrigine during pregnancy. You can enroll by calling 1-888-233-2334.
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How to Read This acetaminophen/oxycodone vs lamotrigine Comparison
acetaminophen/oxycodone is classified in the Opioid Analgesic Combination drug class, while lamotrigine sits within the Anticonvulsant class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acetaminophen/oxycodone has 144,385 submissions while lamotrigine has 32,769. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this combination can lower the amount of lamotrigine in your blood, which may make the medicine less effective.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for acetaminophen/oxycodone or lamotrigine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.