FDA pharmacologic class
Topoisomerase Inhibitor
4 medicines are in FDA's class of topoisomerase inhibitors: irinotecan (Onivyde), etoposide (Vepesid), topotecan (Hycamtin) and mitoxantrone. All 4 are listed from generic labelers (FDA NDC Directory, October 8, 2026).
Which medicines are topoisomerase inhibitor?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Irinotecan | Camptosar, Onivyde | 12 labelers | n/a | Yes | A presentation being discontinued | 9 |
| Etoposide | Avopef, Vepesid, Etopophos | 6 labelers | n/a | Yes | No current entry | 1 |
| Topotecan | Hycamtin | 4 labelers | n/a | Yes | No current entry | 1 |
| Mitoxantrone | none listed | 3 labelers | n/a | Yes | No current entry | 1 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)