FDA pharmacologic class
Sphingosine 1-phosphate Receptor Modulator
5 medicines are in FDA's class of sphingosine 1-phosphate receptor modulators: fingolimod (Gilenya), siponimod (Mayzent), ponesimod (Ponvory), ozanimod (Zeposia) and etrasimod arginine (Velsipity). 1 of the 5 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is fingolimod 0.5 mg capsule at $1.58 per capsule (NADAC).
Which medicines are sphingosine 1-phosphate receptor modulator?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Fingolimod | Tascenso, Gilenya | 21 labelers | $1.58 per capsule 0.5 mg capsule | No | No current entry | 1 |
| Siponimod | Mayzent | none listed | n/a | No | No current entry | 0 |
| Ponesimod | Ponvory | none listed | n/a | No | No current entry | 0 |
| Ozanimod | Zeposia | none listed | n/a | No | No current entry | 0 |
| Etrasimod arginine | Velsipity | none listed | n/a | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price