FDA pharmacologic class
SNRIs (serotonin and norepinephrine reuptake inhibitors)
5 medicines are in FDA's class of serotonin and norepinephrine reuptake inhibitors (SNRIs): venlafaxine (Effexor), duloxetine (Drizalma), desvenlafaxine (Pristiq), milnacipran (Savella) and levomilnacipran (Fetzima). 4 of the 5 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is venlafaxine hcl er 75 mg capsule at $0.0799 per capsule (NADAC).
Which medicines are snris?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Venlafaxine | Effexor | 61 labelers | $0.0799 per capsule 75 mg capsule | Yes | No current entry | 21 |
| Duloxetine | Drizalma | 45 labelers | $0.102 per capsule 30 mg capsule | Yes | No current entry | 56 |
| Desvenlafaxine | Pristiq | 20 labelers | $0.396 per unit 50 mg | Yes | No current entry | 2 |
| Milnacipran | Savella | 4 labelers | $2.82 per tablet 100 mg tablet | Yes | No current entry | 0 |
| Levomilnacipran | Fetzima | none listed | $17.61 per unit 20-40 mg titration pak | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price