FDA pharmacologic class
Sigma-1 Agonist
1 medicine is in FDA's class of sigma-1 agonists: dextromethorphan (Delsym); 6 combination products also contain one. 5 of the 7 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is ft tussin dm 200-20 mg/20 ml at $0.0207 per mL (NADAC).
Which medicines are sigma-1 agonist?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Dextromethorphan and guaifenesin | Mucinex | 58 labelers | $0.0207 per mL 200-20 mg/20 mL | No | No current entry | 1 |
| Dextromethorphan | Delsym | 28 labelers | $0.122 per unit 15 mg softgel | No | No current entry | 0 |
| Brompheniramine and dextromethorphan and pseudoephedrine | none listed | 14 labelers | $0.0682 per mL 2-30-10 mg/5 mL | No | No current entry | 1 |
| Dextromethorphan and promethazine | none listed | 12 labelers | $0.039 per mL 6.25-15 mg/5 mL solution | Yes | No current entry | 0 |
| Dextromethorphan and quinidine | Nuedexta | 4 labelers | $26.64 per capsule 20-10 mg capsule | No | No current entry | 1 |
| Bupropion and dextromethorphan | Auvelity | none listed | $19.90 per tablet 45-105 mg tablet | Yes | No current entry | 0 |
| Dextromethorphan and guaifenesin and naproxen | Mucinex | none listed | n/a | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price