FDA pharmacologic class
Progestins
6 medicines are in FDA's class of progestins (progestins): levonorgestrel (Plan), medroxyprogesterone (Depo-Provera), norethindrone (Errin), megestrol, hydroxyprogesterone caproate and etonogestrel (Nexplanon); 10 combination products also contain one. 10 of the 16 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is falmina-28 tablet at $0.154 per tablet (NADAC).
Which medicines are progestins?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Levonorgestrel | Plan, Mirena, Kyleena | 31 labelers | $6.33 per tablet 1.5 mg tablet | No | No current entry | 3 |
| Ethinyl estradiol and norethindrone | Femlyv, Nortrel, Alyacen | 18 labelers | $0.181 per tablet 21 1-20 tablet | Yes | No current entry | 8 |
| Ethinyl estradiol and levonorgestrel | Twirla, Tyblume, Balcoltra | 19 labelers | $0.154 per tablet 28 tablet | Yes | No current entry | 9 |
| Medroxyprogesterone | Provera, Depo-Provera, Depo-Subq | 21 labelers | $22.85 per mL 150 mg/mL | Yes | A presentation being discontinued | 14 |
| Norethindrone | Errin, Affodel, Lyleq | 18 labelers | $0.290 per tablet 5 mg tablet | No | No current entry | 0 |
| Megestrol | none listed | 17 labelers | $0.241 per tablet 40 mg tablet | No | No current entry | 4 |
| Estradiol and norethindrone | Lopreeza, Combipatch, Activella | 7 labelers | $0.802 per tablet 0.5-0.1 mg tablet | Yes | No current entry | 4 |
| Ethinyl estradiol and etonogestrel | Nuvaring, Eluryng, Enilloring | 5 labelers | $46.35 per ring Etonogestrel-ee vaginal ring | Yes | No current entry | 0 |
| Ethinyl estradiol and norelgestromin | Gwyn, Zafemy, Xulane | 8 labelers | $37.16 per patch 150-35 mcg/day patch | Yes | No current entry | 0 |
| Estrogens conjugated and medroxyprogesterone | Prempro | none listed | $8.68 per tablet 0.3 mg-1.5 mg tablet | No | No current entry | 0 |
| Drospirenone and estradiol | Angeliq | none listed | $6.37 per tablet 0.25 mg-0.5 mg tablet | Yes | No current entry | 0 |
| Ethinyl estradiol and segesterone | Annovera | none listed | $2,315.29 per ring Annovera vaginal ring | Yes | No current entry | 0 |
| Hydroxyprogesterone caproate | none listed | 1 labeler | n/a | No | No current entry | 0 |
| Estradiol and levonorgestrel | Climara | none listed | $59.64 per patch Climara pro patch | Yes | No current entry | 0 |
| Estradiol and norethindrone and relugolix | Myfembree | none listed | $45.25 per tablet 40 mg-1 mg-0.5 mg tablet | Yes | No current entry | 0 |
| Etonogestrel | Nexplanon | none listed | n/a | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price