FDA pharmacologic class
Nitrogen Binding Agent
2 medicines are in FDA's class of nitrogen binding agents: sodium phenylbutyrate (Buphenyl) and glycerol phenylbutyrate (Ravicti); 1 combination product also contains one. All 3 are listed from generic labelers (FDA NDC Directory, October 8, 2026).
Which medicines are nitrogen binding agent?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Sodium phenylbutyrate | Olpruva, Buphenyl, Pheburane | 4 labelers | n/a | No | No current entry | 2 |
| Sodium benzoate and sodium phenylacetate | none listed | 5 labelers | n/a | No | No current entry | 0 |
| Glycerol phenylbutyrate | Ravicti | 7 labelers | n/a | No | A presentation being discontinued | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)