FDA pharmacologic class
Folate Analog Metabolic Inhibitor
3 medicines are in FDA's class of folate analog metabolic inhibitors: methotrexate (Rasuvo), pemetrexed (Alimta) and pralatrexate (Folotyn). All 3 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is methotrexate 2.5 mg tablet at $0.158 per tablet (NADAC).
Which medicines are folate analog metabolic inhibitor?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Methotrexate | Rasuvo, Otrexup, Jylamvo | 29 labelers | $0.158 per tablet 2.5 mg tablet | Yes | In shortage | 8 |
| Pemetrexed | Pemrydi, Alimta, Axtle | 15 labelers | n/a | No | A presentation being discontinued | 5 |
| Pralatrexate | Folotyn | 1 labeler | n/a | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price