FDA pharmacologic class
Endothelin Receptor Antagonist
6 medicines are in FDA's class of endothelin receptor antagonists: ambrisentan (Letairis), macitentan (Opsumit), bosentan (Tracleer), aprocitentan (Tryvio), sparsentan (Filspari) and atrasentan (Vanrafia); 1 combination product also contains one. 3 of the 7 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is ambrisentan 10 mg tablet at $8.02 per tablet (NADAC).
Which medicines are endothelin receptor antagonist?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Ambrisentan | Letairis | 12 labelers | $8.02 per tablet 10 mg tablet | Yes | No current entry | 0 |
| Macitentan | Opsumit | 13 labelers | n/a | Yes | No current entry | 0 |
| Bosentan | Tracleer | 5 labelers | n/a | Yes | No current entry | 0 |
| Aprocitentan | Tryvio | none listed | n/a | Yes | No current entry | 0 |
| Macitentan and tadalafil | Opsynvi | none listed | n/a | Yes | No current entry | 0 |
| Sparsentan | Filspari | none listed | n/a | Yes | No current entry | 0 |
| Atrasentan | Vanrafia | none listed | n/a | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price