FDA pharmacologic class
Dihydrofolate Reductase Inhibitor Antibacterial
1 medicine is in FDA's class of dihydrofolate reductase inhibitor antibacterials: trimethoprim; 2 combination products also contain one. All 3 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is sulfamethoxazole-tmp ds tablet at $0.0448 per tablet (NADAC).
Which medicines are dihydrofolate reductase inhibitor antibacterial?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Sulfamethoxazole and trimethoprim | Sulfatrim, Bactrim, Sulfamethox-Tmp | 44 labelers | $0.0448 per tablet Sulfamethoxazole-tmp ds tablet | No | No current entry | 12 |
| Polymyxin b and trimethoprim | none listed | 10 labelers | $0.452 per mL Polymyxin b-tmp eye drops | No | No current entry | 1 |
| Trimethoprim | none listed | 4 labelers | $1.31 per tablet 100 mg tablet | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price