FDA pharmacologic class
Catechol-O-Methyltransferase Inhibitor
3 medicines are in FDA's class of catechol-o-methyltransferase inhibitors: entacapone, tolcapone (Tasmar) and opicapone (Ongentys); 1 combination product also contains one. 3 of the 4 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is entacapone 200 mg tablet at $0.325 per tablet (NADAC).
Which medicines are catechol-o-methyltransferase inhibitor?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Carbidopa and entacapone and levodopa | none listed | 4 labelers | $0.695 per tablet 25-100-200 mg tablet | No | No current entry | 1 |
| Entacapone | none listed | 11 labelers | $0.325 per tablet 200 mg tablet | No | No current entry | 1 |
| Tolcapone | Tasmar | 1 labeler | n/a | Yes | No current entry | 0 |
| Opicapone | Ongentys | none listed | $24.67 per capsule 25 mg capsule | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price