FDA pharmacologic class
Calcineurin Inhibitor Immunosuppressant
4 medicines are in FDA's class of calcineurin inhibitor immunosuppressants: tacrolimus (Prograf), cyclosporine (Restasis), pimecrolimus and voclosporin (Lupkynis). 3 of the 4 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is tacrolimus 0.1% ointment at $0.970 per gram (NADAC).
Which medicines are calcineurin inhibitor immunosuppressant?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Tacrolimus | Prograf, Astagraf, Envarsus | 33 labelers | $0.970 per gram 0.1% ointment | Yes | No current entry | 9 |
| Cyclosporine | Sandimmune, Neoral, Restasis | 14 labelers | $1.04 per unit 0.05% eye emulsion | Yes | No current entry | 7 |
| Pimecrolimus | none listed | 2 labelers | $3.31 per gram 1% cream | Yes | No current entry | 0 |
| Voclosporin | Lupkynis | none listed | n/a | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price