FDA pharmacologic class
Biguanides (metformin)
1 medicine is in FDA's class of biguanides (biguanides): metformin (Glumetza); 12 combination products also contain one. 8 of the 13 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is metformin hcl 500 mg tablet at $0.0145 per tablet (NADAC).
Which medicines are biguanides?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Metformin | Glumetza, Riomet | 80 labelers | $0.0145 per tablet 500 mg tablet | Yes | No current entry | 61 |
| Dapagliflozin and metformin | Xigduo | 8 labelers | $0.720 per tablet 10-1,000 mg tablet | Yes | No current entry | 2 |
| Metformin and sitagliptin | Zituvimet, Janumet | 4 labelers | $1.76 per tablet 50 mg-1,000 mg tablet | Yes | No current entry | 1 |
| Glyburide and metformin | Glyburide-Metformin | 11 labelers | $0.171 per unit 2.5-500 mg | Yes | No current entry | 1 |
| Glipizide and metformin | none listed | 9 labelers | $0.242 per unit 2.5-250 mg | No | No current entry | 1 |
| Metformin and pioglitazone | Actoplus | 5 labelers | $0.283 per unit 15-500 | Yes | No current entry | 1 |
| Canagliflozin and metformin | Invokamet | none listed | $9.58 per tablet 150-1,000 mg tablet | Yes | No current entry | 1 |
| Empagliflozin and metformin | Synjardy | none listed | $5.60 per tablet 12.5-1,000 mg tablet | Yes | No current entry | 4 |
| Linagliptin and metformin | Jentadueto | 1 labeler | $8.44 per tablet 2.5 mg-1,000 mg tablet | Yes | No current entry | 1 |
| Metformin and saxagliptin | none listed | 2 labelers | $9.65 per tablet 5-1,000 mg tablet | Yes | No current entry | 0 |
| Alogliptin and metformin | Kazano | none listed | $2.46 per unit 12.5-1000 | Yes | No current entry | 0 |
| Empagliflozin and linagliptin and metformin | Trijardy | none listed | $11.28 per tablet 10-5-1,000 mg tablet | Yes | No current entry | 0 |
| Ertugliflozin and metformin | Segluromet | none listed | $5.76 per tablet 2.5-1,000 mg tablet | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price