FDA pharmacologic class
Antihistamines
3 medicines are in FDA's class of antihistamines (antihistamines): hydroxyzine, benztropine and doxylamine; 1 combination product also contains one. All 4 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is hydroxyzine hcl 25 mg tablet at $0.0326 per tablet (NADAC).
Which medicines are antihistamines?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Hydroxyzine | none listed | 61 labelers | $0.0326 per tablet 25 mg tablet | No | No current entry | 18 |
| Benztropine | none listed | 23 labelers | $0.0753 per tablet 1 mg tablet | No | A presentation being discontinued | 3 |
| Doxylamine | none listed | 35 labelers | $0.116 per tablet 25 mg tablet | No | A presentation being discontinued | 0 |
| Doxylamine and pyridoxine | Bonjesta, Diclegis | 4 labelers | $1.09 per unit 10-10 mg | No | No current entry | 2 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price