FDA pharmacologic class
alpha-Adrenergic Agonist
6 medicines are in FDA's class of alpha-adrenergic agonists: epinephrine (Neffy), midodrine, pseudoephedrine, ephedrine (Akovaz), brimonidine (Lumify) and apraclonidine (Iopidine); 16 combination products also contain one. 16 of the 22 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is bromphen-pse-dm 2-30-10 mg/5 ml at $0.0682 per mL (NADAC).
Which medicines are alpha-adrenergic agonist?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Epinephrine | Adrenalin, Auvi-Q, Neffy | 16 labelers | $123.51 per unit 0.15 mg auto-injct | No | A presentation being discontinued | 29 |
| Midodrine | none listed | 33 labelers | $0.111 per tablet 5 mg tablet | Yes | No current entry | 1 |
| Pseudoephedrine | none listed | 34 labelers | $0.281 per tablet 120 mg tablet | No | No current entry | 3 |
| Epinephrine and lidocaine | Xylocaine, Xylocaine-Mpf, Flavalta | 17 labelers | $0.139 per mL 1%-epi 1:100,000 | No | In shortage | 9 |
| Guaifenesin and pseudoephedrine | Mucinex | 28 labelers | $0.384 per unit 600-60 mg | No | No current entry | 0 |
| Loratadine and pseudoephedrine | Claritin-D | 29 labelers | $0.553 per tablet Allergy relief-nasal decong tablet | No | No current entry | 3 |
| Ephedrine | Emerphed, Akovaz | 19 labelers | n/a | No | No current entry | 20 |
| Fexofenadine and pseudoephedrine | Allegra-D | 26 labelers | $0.483 per tablet 60-120 tablet | No | No current entry | 5 |
| Brimonidine | Lumify, Alphagan, Mirvaso | 14 labelers | $9.06 per mL 0.1% drop | No | No current entry | 4 |
| Cetirizine and pseudoephedrine | Zyrtec-D | 24 labelers | $0.563 per tablet 5-120 mg tablet | No | No current entry | 0 |
| Articaine and epinephrine | Orabloc | none listed | n/a | No | No current entry | 1 |
| Bupivacaine and epinephrine | Sensorcaine, Marcaine | 5 labelers | n/a | Yes | No current entry | 10 |
| Brimonidine and timolol | Combigan | 14 labelers | $2.15 per mL 0.2%-0.5% | No | No current entry | 5 |
| Brompheniramine and dextromethorphan and pseudoephedrine | none listed | 14 labelers | $0.0682 per mL 2-30-10 mg/5 mL | No | No current entry | 1 |
| Ibuprofen and pseudoephedrine | Advil | 9 labelers | n/a | No | No current entry | 0 |
| Naproxen and pseudoephedrine | none listed | 10 labelers | $0.244 per unit 220-120 mg | No | No current entry | 0 |
| Apraclonidine | Iopidine | none listed | $9.29 per mL 0.5% drops | No | No current entry | 1 |
| Epinephrine and prilocaine | Citanest | 2 labelers | n/a | No | No current entry | 0 |
| Brimonidine and brinzolamide | Simbrinza | none listed | $26.04 per mL 1%-0.2% eye drop | No | No current entry | 0 |
| Brimonidine and carbachol | Yuvezzi | none listed | n/a | No | No current entry | 0 |
| Chlorpheniramine and ibuprofen and pseudoephedrine | Advil | none listed | n/a | No | No current entry | 0 |
| Desloratadine and pseudoephedrine | Clarinex-D | none listed | $6.07 per tablet 12 hr 2.5-120 mg tablet | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price