FDA pharmacologic class
alpha-1 Adrenergic Agonist
1 medicine is in FDA's class of alpha-1 adrenergic agonists: phenylephrine (Biorphen); 6 combination products also contain one. 5 of the 7 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is phenylephrine 10% eye drop at $5.24 per mL (NADAC).
Which medicines are alpha-1 adrenergic agonist?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Phenylephrine | Immphentiv, Biorphen | 33 labelers | $5.24 per mL 10% eye drop | No | No current entry | 90 |
| Ibuprofen and phenylephrine | Advil | 3 labelers | n/a | No | No current entry | 0 |
| Chlorpheniramine and ibuprofen and phenylephrine | Advil | none listed | n/a | No | No current entry | 1 |
| Ketorolac and phenylephrine | Omidria | none listed | n/a | No | No current entry | 0 |
| Phenylephrine and promethazine | none listed | 2 labelers | n/a | No | No current entry | 0 |
| Codeine and phenylephrine and promethazine | none listed | 1 labeler | n/a | Yes | No current entry | 0 |
| Cyclopentolate and phenylephrine | Cyclomydril | 1 labeler | n/a | No | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price