Medicines labeled for the same conditions
Alternatives to tofacitinib
10 other medicines are given the same way (oral) and in the same FDA class as tofacitinib or labeled mainly for the same use (rheumatoid arthritis); 2 are in its class, janus kinase inhibitors: upadacitinib and baricitinib; the others include 3 antirheumatic agents, 2 nonsteroidal anti-inflammatory drugs and 1 folate analog metabolic inhibitor (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $92.54 per Olumiant 2 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as tofacitinib?
Rheumatoid arthritis lists all 46 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Tofacitinibjanus kinase inhibitor | this medicine | 24 labelers | $0.573 per tablet 5 mg tablet | Yes | No current entry |
| Upadacitinibjanus kinase inhibitor · same class | Rheumatoid arthritis, Crohn's disease and ulcerative colitis | none listed | $229.31 per tablet 15 mg tablet | Yes | No current entry |
| Baricitinibjanus kinase inhibitor · same class | Rheumatoid arthritis | none listed | $92.54 per tablet 2 mg tablet | Yes | No current entry |
| Indomethacinnonsteroidal anti-inflammatory drug | Rheumatoid arthritis | 25 labelers | $0.210 per capsule 75 mg capsule | Yes | No current entry |
| Hydroxychloroquineantirheumatic agent | Rheumatoid arthritis | 28 labelers | $0.149 per tablet 200 mg tablet | No | A presentation being discontinued |
| Leflunomideantirheumatic agent | Rheumatoid arthritis | 16 labelers | $0.324 per tablet 10 mg tablet | Yes | A presentation being discontinued |
| Methotrexatefolate analog metabolic inhibitor | Rheumatoid arthritis | 25 labelers | $0.158 per tablet 2.5 mg tablet | Yes | In shortage |
| Sulfasalazineaminosalicylate | Rheumatoid arthritis, Crohn's disease and ulcerative colitis | 5 labelers | $0.199 per tablet 500 mg tablet | No | No current entry |
| Penicillamineantirheumatic agent | Rheumatoid arthritis | 9 labelers | n/a | Yes | No current entry |
| Flurbiprofennonsteroidal anti-inflammatory drug | Rheumatoid arthritis | 3 labelers | $3.17 per tablet 100 mg tablet | No | No current entry |
| Auranofin | Rheumatoid arthritis | none listed | $24.85 per capsule 3 mg capsule | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Tofacitinib: the full record
- label, generics, price, shortages, recalls
- Methotrexate vs tofacitinib
- two records side by side
- Tofacitinib vs sulfasalazine
- two records side by side