Medicines labeled for the same conditions
Alternatives to siponimod
8 other medicines are given the same way (oral) and in the same FDA class as siponimod or labeled mainly for the same use (multiple sclerosis); 2 are in its class, sphingosine 1-phosphate receptor modulators: fingolimod and ponesimod; the others include 1 pyrimidine synthesis inhibitor, 1 potassium channel blocker and 1 purine antimetabolite (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $1.58 per fingolimod 0.5 mg capsule (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as siponimod?
Multiple sclerosis lists all 23 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Siponimodsphingosine 1-phosphate receptor modulator | this medicine | none listed | n/a | No | No current entry |
| Fingolimodsphingosine 1-phosphate receptor modulator · same class | Multiple sclerosis | 21 labelers | $1.58 per capsule 0.5 mg capsule | No | No current entry |
| Ponesimodsphingosine 1-phosphate receptor modulator · same class | Multiple sclerosis | none listed | n/a | No | No current entry |
| Dimethyl fumarate | Multiple sclerosis | 19 labelers | $0.467 per capsule 240 mg capsule | No | No current entry |
| Teriflunomidepyrimidine synthesis inhibitor | Multiple sclerosis | 15 labelers | $0.233 per tablet 14 mg tablet | Yes | No current entry |
| Dalfampridinepotassium channel blocker | Multiple sclerosis | 9 labelers | $0.399 per tablet 10 mg tablet | No | No current entry |
| Cladribinepurine antimetabolite | Multiple sclerosis | 3 labelers | n/a | Yes | No current entry |
| Diroximel fumarate | Multiple sclerosis | none listed | n/a | No | No current entry |
| Monomethyl fumarate | Multiple sclerosis | none listed | n/a | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Siponimod: the full record
- label, generics, price, shortages, recalls