Medicines labeled for the same conditions
Alternatives to sildenafil
4 other medicines are given the same way (oral) and in the same FDA class as sildenafil or labeled mainly for the same use (erectile dysfunction); 4 are in its class, phosphodiesterase 5 inhibitors: tadalafil, vardenafil, avanafil and macitentan and tadalafil (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.167 per tadalafil 20 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as sildenafil?
Erectile dysfunction lists all 5 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Sildenafilphosphodiesterase 5 inhibitor | this medicine | 59 labelers | $0.132 per tablet 100 mg tablet | No | No current entry |
| Tadalafilphosphodiesterase 5 inhibitor · same class | Pulmonary arterial hypertension, Erectile dysfunction | 50 labelers | $0.167 per tablet 20 mg tablet | No | No current entry |
| Vardenafilphosphodiesterase 5 inhibitor · same class | Erectile dysfunction | 11 labelers | $2.79 per tablet 20 mg tablet | No | No current entry |
| Avanafilphosphodiesterase 5 inhibitor · same class | Erectile dysfunction | 1 labeler | $50.00 per tablet 200 mg tablet | No | No current entry |
| Macitentan and tadalafilphosphodiesterase 5 inhibitor · same class | Pulmonary arterial hypertension | none listed | n/a | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Sildenafil: the full record
- label, generics, price, shortages, recalls
- Sildenafil vs tadalafil
- two records side by side
- Sildenafil vs vardenafil
- two records side by side