romosozumab
Brand names: Evenity
Evenity is a medicine to treat osteoporosis in women after menopause who are at high risk for bone fracture. It can help make your bones stronger.
What it does
Evenity treats osteoporosis in women after menopause.
Common side effects
Joint pain, Headache
Key warnings
Evenity may increase your risk of heart attack, stroke, and death from heart problems.
How It Works
Evenity works by blocking a protein called sclerostin. Sclerostin slows down new bone formation. By blocking sclerostin, Evenity helps your body build new bone and increase bone strength.
How to Take It
Evenity is given as two separate shots under the skin (subcutaneously) by a healthcare provider. You will receive a 210 mg dose once a month for 12 months. The shots are given in your stomach area, thigh, or upper arm. Make sure you also take enough calcium and vitamin D during your treatment.
Pregnancy & Breastfeeding
Evenity is not for women who could become pregnant. Animal studies showed harm to the baby when Evenity was given to pregnant animals. It is also unknown if Evenity passes into breast milk.
Missed Dose
If you miss a dose of Evenity, get the shot as soon as you can reschedule. Then, you can get Evenity every month from the date of your last dose.
Storage
Keep Evenity in the refrigerator between 36°F and 46°F (2°C to 8°C) in its original carton to protect it from light. Do not freeze or shake it.
Serious Warnings
Evenity may increase your risk of heart attack, stroke, and death from heart problems. You should not start Evenity if you have had a heart attack or stroke in the past year. Your doctor will consider if the benefits of Evenity outweigh these risks if you have other heart risk factors. If you have a heart attack or stroke while taking Evenity, stop taking it.
Common Questions
Who should not take Evenity?
How long can I take Evenity?
What should I do if I have symptoms of a heart attack or stroke?
Can Evenity cause allergic reactions?
Will I need to take calcium and vitamin D while using Evenity?
What are the signs of low calcium?
Can Evenity cause jaw problems?
What are the symptoms of an unusual thigh pain?
How is Evenity supplied?
What if Evenity is left out of the refrigerator?
What are the common side effects of romosozumab?
What drug class is romosozumab?
Is romosozumab safe during pregnancy?
Has romosozumab been recalled?
Active Recalls
CGMP Deviations; potential temperature excursions due to transit delays
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Related Medications in Sclerostin Inhibitor
Other drugs grouped near romosozumab — same-class peers and common alternatives.
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alendronate
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calcitonin
Miacalcin, Fortical
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denosumab
Prolia, Xgeva
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ibandronate
Boniva
Ibandronate (Boniva) is a medicine that helps treat and prevent bone loss in women after menopause.
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What the FDA Data Shows for romosozumab
The FDA label for romosozumab (sold under brand names such as Evenity) classifies it as a prescription-only medication in the Sclerostin Inhibitor class. Evenity treats osteoporosis in women after menopause. Official labeling lists 2 commonly reported side effects, including Joint pain, Headache.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. Interaction data is drawn directly from FDA-approved prescribing information. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 1 recall record on file), and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: January 8, 2026
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages