Medicines labeled for the same conditions
Alternatives to riociguat
6 other medicines are given the same way (oral) and in the same FDA class as riociguat or labeled mainly for the same use (pulmonary arterial hypertension); the others include 3 endothelin receptor antagonists, 1 prostacyclin receptor agonist and 1 prostacycline vasodilator (FDA labels read October 8, 2026).
Which medicines are labeled for the same conditions as riociguat?
Pulmonary arterial hypertension lists all 11 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Riociguatsoluble guanylate cyclase stimulator | this medicine | 1 labeler | n/a | Yes | No current entry |
| Ambrisentanendothelin receptor antagonist | Pulmonary arterial hypertension | 12 labelers | $8.02 per tablet 10 mg tablet | Yes | No current entry |
| Selexipagprostacyclin receptor agonist | Pulmonary arterial hypertension | 2 labelers | n/a | No | No current entry |
| Treprostinilprostacycline vasodilator | Pulmonary arterial hypertension | none listed | n/a | No | No current entry |
| Bosentanendothelin receptor antagonist | Pulmonary arterial hypertension | 5 labelers | n/a | Yes | No current entry |
| Macitentanendothelin receptor antagonist | Pulmonary arterial hypertension | 13 labelers | n/a | Yes | No current entry |
| Macitentan and tadalafilphosphodiesterase 5 inhibitor | Pulmonary arterial hypertension | none listed | n/a | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Riociguat: the full record
- label, generics, price, shortages, recalls