Medicines labeled for the same conditions
Alternatives to orforglipron
8 other medicines are given the same way (oral) and in the same FDA class as orforglipron or labeled mainly for the same use (weight management); 1 is in its class, GLP-1 receptor agonists: semaglutide; the others include 5 sympathomimetic amine anorectics, 1 intestinal lipase inhibitor and 1 aminoketone (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $33.13 per Ozempic 1.5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as orforglipron?
Weight management lists all 12 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| OrforglipronGLP-1 receptor agonist | this medicine | none listed | $20.89 per tablet 0.8 mg tablet | Yes | No current entry |
| SemaglutideGLP-1 receptor agonist · same class | Weight management | none listed | $33.13 per tablet 1.5 mg tablet | Yes | A presentation being discontinued |
| Phenterminesympathomimetic amine anorectic | Weight management | 27 labelers | $0.0727 per tablet 37.5 mg tablet | No | No current entry |
| Diethylpropionsympathomimetic amine anorectic | Weight management | 13 labelers | $0.238 per tablet 25 mg tablet | No | No current entry |
| Phendimetrazinesympathomimetic amine anorectic | Weight management | 11 labelers | $0.132 per tablet 35 mg tablet | No | No current entry |
| Phentermine and topiramatesympathomimetic amine anorectic | Weight management | 2 labelers | $3.06 per capsule 7.5-46 mg capsule | No | No current entry |
| Benzphetaminesympathomimetic amine anorectic | Weight management | 6 labelers | n/a | No | No current entry |
| Orlistatintestinal lipase inhibitor | Weight management | none listed | $7.00 per capsule 120 mg capsule | No | No current entry |
| Bupropion and naltrexoneaminoketone | Weight management | none listed | n/a | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Orforglipron: the full record
- label, generics, price, shortages, recalls