Medicines labeled for the same conditions
Alternatives to macitentan and tadalafil
6 other medicines are given the same way (oral) and in the same FDA class as macitentan and tadalafil or labeled mainly for the same use (pulmonary arterial hypertension); 3 are in its class, phosphodiesterase 5 inhibitors: sildenafil, ambrisentan and bosentan; the others include 1 prostacyclin receptor agonist, 1 prostacycline vasodilator and 1 soluble guanylate cyclase stimulator (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.132 per sildenafil 100 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as macitentan and tadalafil?
Pulmonary arterial hypertension lists all 11 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Macitentan and tadalafilphosphodiesterase 5 inhibitor | this medicine | none listed | n/a | Yes | No current entry |
| Sildenafilphosphodiesterase 5 inhibitor · same class | Pulmonary arterial hypertension | 59 labelers | $0.132 per tablet 100 mg tablet | No | No current entry |
| Ambrisentanendothelin receptor antagonist · same class | Pulmonary arterial hypertension | 12 labelers | $8.02 per tablet 10 mg tablet | Yes | No current entry |
| Bosentanendothelin receptor antagonist · same class | Pulmonary arterial hypertension | 5 labelers | n/a | Yes | No current entry |
| Selexipagprostacyclin receptor agonist | Pulmonary arterial hypertension | 2 labelers | n/a | No | No current entry |
| Treprostinilprostacycline vasodilator | Pulmonary arterial hypertension | none listed | n/a | No | No current entry |
| Riociguatsoluble guanylate cyclase stimulator | Pulmonary arterial hypertension | 1 labeler | n/a | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Macitentan and tadalafil: the full record
- label, generics, price, shortages, recalls