Alternatives to leflunomide
3 same-class SPL records vs leflunomide - uses, FAERS reaction fields, and OTC/Rx flags from public FDA sources.
Brand: Arava
How to read a high-report FAERS peer set
leflunomide ranks in the upper FAERS-volume third of the corpus (#77 of 524); 3 same-class peers are listed for field comparison only. Labeled indication field for leflunomide: Leflunomide treats active rheumatoid arthritis in adults.
Top FAERS reaction fields for leflunomide total 152,042 reports across 10 reactions, set beside hydroxychloroquine, methotrexate, sulfasalazine. Counts are exposure-weighted submissions, not per-patient risk.
About leflunomide
Leflunomide is a drug that can help reduce the symptoms of rheumatoid arthritis. It works by slowing down the body's immune system.
Used for: Leflunomide treats active rheumatoid arthritis in adults. Rheumatoid arthritis is a disease that causes pain, swelling, and stiffness in the joints. This medicine can help reduce these symptoms.
3 Disease-Modifying Antirheumatic Drug (DMARD) peers (wide set)
hydroxychloroquine
RxPlaquenil
This medicine can treat uncomplicated malaria caused by certain parasites. It can also prevent malaria in areas where the parasites are not resistant to the drug. Hydroxychloroquine also treats rheumatoid arthritis, systemic lupus erythematosus, and chronic discoid lupus erythematosus.
methotrexate
RxTrexall, Otrexup
Methotrexate can treat acute lymphoblastic leukemia, a type of cancer, in adults and children. It also treats mycosis fungoides, a skin lymphoma, in adults. Additionally, it treats relapsed or refractory non-Hodgkin lymphoma in adults. For non-cancer conditions, it treats rheumatoid arthritis in adults, polyarticular juvenile idiopathic arthritis (pJIA) in children, and severe psoriasis in adults.
sulfasalazine
RxAzulfidine
Sulfasalazine treats ulcerative colitis, a condition that causes inflammation and sores in the lining of the large intestine. It can help with mild to moderate ulcerative colitis. It can also be used with other treatments for severe ulcerative colitis. This medicine can also help keep ulcerative colitis from coming back.
leflunomide vs hydroxychloroquine & methotrexate · FAERS reaction fields
FAERS top-reaction field "Arthralgia" shows the widest count spread between leflunomide and hydroxychloroquine, methotrexate, sulfasalazine in this extract (19,342-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | leflunomide | hydroxychloroquine | methotrexate | sulfasalazine |
|---|---|---|---|---|
| Rheumatoid Arthritis | 24,923 | 12,921 | 38,053 | 19,190 |
| Pain | 20,055 | 10,409 | 35,413 | 15,658 |
| Arthralgia | 16,941 | 9,276 | 36,283 | 13,161 |
| Joint Swelling | 15,567 | 8,528 | 22,294 | 12,481 |
| Fatigue | 15,384 | 8,853 | 29,061 | 13,017 |
| Rash | 13,321 | 7,370 | 19,771 | 10,678 |
| Abdominal Discomfort | 11,731 | 5,881 | - | 9,801 |
| Alopecia | 11,692 | 5,939 | 14,713 | 9,277 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
leflunomide FAERS volume vs class peers
FAERS volume band
leflunomide is FAERS corpus rank #77 of 524 (high volume tercile). Top-reaction field total: 152,042.
Frequently Asked Questions
Where does leflunomide sit in FAERS report volume vs Disease-Modifying Antirheumatic Drug (DMARD) peers? ▼
Registry note: FAERS counts are voluntary reports and do not establish causation or risk rates. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for leflunomide: see also the generic vs brand label guide when reading Arava SPL strings.
Read our methodology - how this data is sourced, computed, and verified.