Medicines labeled for the same conditions
Alternatives to atropine and diphenoxylate
9 other medicines are given the same way (oral) and in the same FDA class as atropine and diphenoxylate or labeled mainly for the same use (diarrhea); 1 is in its class, antidiarrheals: crofelemer; the others include 2 opioid agonists, 1 fluoroquinolone antibacterial and 1 antiprotozoal (FDA labels read October 8, 2026).
Which medicines are labeled for the same conditions as atropine and diphenoxylate?
Diarrhea lists all 16 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Atropine and diphenoxylateantidiarrheal | this medicine | 19 labelers | $0.139 per tablet 2.5-0.025 mg tablet | No | No current entry |
| Crofelemerantidiarrheal · same class | Diarrhea | none listed | n/a | No | No current entry |
| Bismuth subsalicylate | Diarrhea | none listed | $0.0817 per tablet 262 mg tablet chewable | No | No current entry |
| Loperamideopioid agonist | Diarrhea | 98 labelers | $0.0549 per capsule 2 mg capsule | Yes | No current entry |
| Ciprofloxacinfluoroquinolone antibacterial | Diarrhea | 46 labelers | $0.123 per tablet 500 mg tablet | Yes | No current entry |
| Dimethicone and loperamideopioid agonist | Diarrhea | 33 labelers | $0.286 per unit Gs anti-diarrheal-antigas cplt | No | No current entry |
| Nitazoxanideantiprotozoal | Diarrhea | 4 labelers | $82.20 per tablet 500 mg tablet | No | No current entry |
| Rifaximinrifamycin antibacterial | Diarrhea | none listed | n/a | No | No current entry |
| Octreotidesomatostatin analog | Diarrhea | none listed | n/a | No | No current entry |
| Telotristattryptophan hydroxylase inhibitor | Diarrhea | none listed | n/a | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Atropine and diphenoxylate: the full record
- label, generics, price, shortages, recalls