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Medicines labeled for the same conditions

Alternatives to dalfampridine

8 other medicines are given the same way (oral) and in the same FDA class as dalfampridine or labeled mainly for the same use (multiple sclerosis); the others include 3 sphingosine 1-phosphate receptor modulators, 1 pyrimidine synthesis inhibitor and 1 purine antimetabolite (FDA labels read October 8, 2026).

Which medicines are labeled for the same conditions as dalfampridine?

Multiple sclerosis lists all 23 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA classShared indicationGeneric labelers (oral)Pharmacy costBoxed warningShortage
Dalfampridinepotassium channel blockerthis medicine9 labelers$0.399 per tablet 10 mg tabletNoNo current entry
Dimethyl fumarateMultiple sclerosis19 labelers$0.467 per capsule 240 mg capsuleNoNo current entry
Teriflunomidepyrimidine synthesis inhibitorMultiple sclerosis15 labelers$0.233 per tablet 14 mg tabletYesNo current entry
Fingolimodsphingosine 1-phosphate receptor modulatorMultiple sclerosis21 labelers$1.58 per capsule 0.5 mg capsuleNoNo current entry
Cladribinepurine antimetaboliteMultiple sclerosis3 labelersn/aYesNo current entry
Siponimodsphingosine 1-phosphate receptor modulatorMultiple sclerosisnone listedn/aNoNo current entry
Ponesimodsphingosine 1-phosphate receptor modulatorMultiple sclerosisnone listedn/aNoNo current entry
Diroximel fumarateMultiple sclerosisnone listedn/aNoNo current entry
Monomethyl fumarateMultiple sclerosisnone listedn/aNoNo current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Dalfampridine: the full record
label, generics, price, shortages, recalls