Medicines labeled for the same conditions

Alternatives to chlorpheniramine and hydrocodone

16 other medicines are given the same way (oral) and in the same FDA class as chlorpheniramine and hydrocodone or labeled mainly for the same use (cough and cold); 4 are in its class, histamine-1 receptor antagonists: diphenhydramine, fexofenadine and pseudoephedrine, codeine and promethazine and codeine and phenylephrine and promethazine; the others include 4 alpha-adrenergic agonists, 3 expectorants and 2 sigma-1 agonists (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0185 per mL (Child allergy rlf 12.5 mg/5 mL) (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as chlorpheniramine and hydrocodone?

Cough and cold lists all 31 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA class	Shared indication	Generic labelers (oral)	Pharmacy cost	Boxed warning	Shortage
Chlorpheniramine and hydrocodonehistamine-1 receptor antagonist	this medicine	2 labelers	$0.556 per mL Hydrocodone-chlorphen ER suspension	Yes	No current entry
Diphenhydraminehistamine-1 receptor antagonist · same class	Cough and cold	4 labelers	$0.0185 per mL 12.5 mg/5 mL	No	No current entry
Fexofenadine and pseudoephedrinehistamine-1 receptor antagonist · same class	Cough and cold	27 labelers	$0.483 per tablet 60-120 tablet	No	No current entry
Codeine and promethazinephenothiazine · same class	Cough and cold	5 labelers	$0.0697 per mL Promethazine-codeine solution	Yes	No current entry
Codeine and phenylephrine and promethazinealpha-1 adrenergic agonist · same class	Cough and cold	1 labeler	n/a	Yes	No current entry
Dextromethorphan and guaifenesinexpectorant	Cough and cold	61 labelers	$0.0207 per mL 200-20 mg/20 mL	No	No current entry
Guaifenesinexpectorant	Cough and cold	102 labelers	$0.284 per tablet 600 mg tablet	No	No current entry
Benzonatatenon-narcotic antitussive	Cough and cold	45 labelers	$0.0656 per capsule 100 mg capsule	No	No current entry
Dextromethorphansigma-1 agonist	Cough and cold	28 labelers	$0.122 per unit 15 mg softgel	No	No current entry
Pseudoephedrinealpha-adrenergic agonist	Cough and cold	34 labelers	$0.281 per tablet 120 mg tablet	No	No current entry
Guaifenesin and pseudoephedrineexpectorant	Cough and cold	30 labelers	$0.384 per unit 600-60 mg	No	No current entry
Phenylephrinealpha-1 adrenergic agonist	Cough and cold	none listed	$0.0496 per tablet 10 mg tablet	No	No current entry
Loratadine and pseudoephedrinealpha-adrenergic agonist	Cough and cold	31 labelers	$0.553 per tablet Allergy relief-nasal decong tablet	No	No current entry
Dextromethorphan and promethazinesigma-1 agonist	Cough and cold	13 labelers	$0.039 per mL 6.25-15 mg/5 mL solution	Yes	No current entry
Ibuprofen and pseudoephedrinealpha-adrenergic agonist	Cough and cold	9 labelers	n/a	No	No current entry
Naproxen and pseudoephedrinealpha-adrenergic agonist	Cough and cold	10 labelers	$0.244 per unit 220-120 mg	No	No current entry
Ibuprofen and phenylephrinealpha-1 adrenergic agonist	Cough and cold	3 labelers	n/a	No	No current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Chlorpheniramine and hydrocodone: the full record: label, generics, price, shortages, recalls