baloxavir marboxil
Brand names: Xofluza
Xofluza is an antiviral medicine that can treat the flu. It can also prevent the flu if you have been around someone who is sick.
Drug Pricing (NADAC)
Brand Price
$157.18/unit
Generic Available
No
GENENTECH INC
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Xofluza is used to treat the flu in people 5 years and older.
Common side effects
Diarrhea, Bronchitis, Nausea
Key warnings
Xofluza can cause allergic reactions like anaphylaxis.
How It Works
Xofluza stops the flu virus from making more copies of itself in your body. It does this by blocking a protein the virus needs to grow. This helps you get better faster or prevents you from getting sick.
How to Take It
Take Xofluza as a single dose as soon as possible, but within 48 hours of when your flu symptoms started or after you were exposed to the flu. You can take Xofluza with or without food. The dose you need depends on your weight. If you weigh less than 80 kg (176 lbs), you will take one 40 mg tablet. If you weigh 80 kg (176 lbs) or more, you will take one 80 mg tablet.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant. The benefits of taking Xofluza should be weighed against any potential risks to the baby. It is not known if Xofluza passes into breast milk. Talk to your doctor about the best way to feed your baby if you take Xofluza.
Missed Dose
Xofluza is taken as a single dose, so you don't have to worry about missing a dose.
Storage
Store Xofluza tablets in their original blister package at room temperature, between 68°F and 77°F.
Side Effects (from patient reports)
Based on 1,855 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 2,164 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2017–2025.
Total Reports
2,164
Death-Related Reports
130
Hospitalization Reports
417
Top Indication
Influenza
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | NO ADVERSE EVENT | 518 |
| 2 | OFF LABEL USE | 419 |
| 3 | INTENTIONAL PRODUCT USE ISSUE | 283 |
| 4 | DIARRHOEA | 129 |
| 5 | VOMITING | 120 |
| 6 | PNEUMONIA | 111 |
| 7 | DRUG INEFFECTIVE | 86 |
| 8 | NAUSEA | 70 |
| 9 | RASH | 61 |
| 10 | HEADACHE | 58 |
| 11 | INFLUENZA | 57 |
| 12 | COLITIS ISCHAEMIC | 56 |
| 13 | HYPERPYREXIA | 54 |
| 14 | PYREXIA | 51 |
| 15 | URTICARIA | 42 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Xofluza can cause allergic reactions like anaphylaxis. Get medical help right away if you have trouble breathing, hives, or swelling. Xofluza is not for children under 5 years old because it may not work as well in this age group. Xofluza does not prevent bacterial infections, which can happen with the flu. See a doctor if you think you have a bacterial infection.
Known Drug Interactions
7 DRUG INTERACTIONS Avoid coadministration of XOFLUZA with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, or zinc). Avoid coadministration of XOFLUZA with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, or zinc).
Mechanism: Zinc can bind to this medicine in your stomach and prevent it from being absorbed into your body. This makes the medicine less effective at treating the flu.
What to do: Do not take this medicine at the same time as supplements containing zinc. Avoid these products during your treatment.
7 DRUG INTERACTIONS Avoid coadministration of XOFLUZA with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, or zinc). Avoid coadministration of XOFLUZA with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, or zinc).
Mechanism: Selenium can attach to the medicine in your digestive system and stop it from getting into your bloodstream. This prevents the drug from working correctly.
What to do: Avoid taking selenium supplements at the same time as this medication. Talk to your doctor about when it is safe to take your supplements.
Common Questions
How quickly does Xofluza work?
Can I take Xofluza if I'm allergic to eggs?
Can Xofluza prevent me from spreading the flu to others?
Can I take Xofluza with other medicines?
What if I start feeling worse after taking Xofluza?
Is there a generic version of Xofluza?
How effective is Xofluza?
Can I get the flu again even if I take Xofluza?
Does Xofluza interact with the flu shot?
What should I do if someone in my family has the flu?
What are the common side effects of baloxavir marboxil?
Does baloxavir marboxil interact with other medications?
What drug class is baloxavir marboxil?
Is baloxavir marboxil safe during pregnancy?
Related Medications in Endonuclease Inhibitor (Antiviral)
Other drugs grouped near baloxavir marboxil — same-class peers and common alternatives.
acyclovir
Zovirax
Acyclovir is an antiviral medicine.
Compare with baloxavir marboxil →
albendazole
Albenza
Albendazole is a medicine that fights parasites.
Compare with baloxavir marboxil →
amphotericin B
Ambisome, Fungizone
Amphotericin B liposome is an antifungal medicine.
Compare with baloxavir marboxil →
anidulafungin
Eraxis
Eraxis is an antifungal medicine.
Compare with baloxavir marboxil →
atovaquone/proguanil
Malarone
Malarone is a drug used to prevent and treat malaria.
Compare with baloxavir marboxil →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Related Health & Safety Data
🩺 Find a Doctor
Search prescribers for Endonuclease Inhibitor (Antiviral)
🏨 Hospital Quality
CMS hospital ratings, safety scores & patient outcomes
💊 Supplement Data
NIH DSLD — check supplement ingredients & label claims
🍽️ Food Safety Alerts
FDA recalls, inspections & outbreak investigations
⚠️ Product Recalls
FDA, CPSC & NHTSA recall search
💉 Procedure Costs
Medicare procedure pricing for 9,297 procedures
Save on baloxavir marboxil
Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.
Disclosure: This link may earn us a commission at no extra cost to you. See our terms.
What the FDA Data Shows for baloxavir marboxil
The FDA label for baloxavir marboxil (sold under brand names such as Xofluza) classifies it as a prescription-only medication in the Endonuclease Inhibitor (Antiviral) class. Xofluza is used to treat the flu in people 5 years and older. Official labeling lists 6 commonly reported side effects, including Diarrhea, Bronchitis, Nausea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,855 voluntary reports. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: August 22, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages