Prescription medication · PTHrP Analog
abaloparatide
Also sold as Tymlos. Tymlos treats osteoporosis in women after menopause and in men.
Data updated 2026-05-15
- 24,667
- FDA reportsModerately reported
- $1646.36
- Brand price (NADAC)
abaloparatide (Tymlos) is a prescription PTHrP Analog. Tymlos treats osteoporosis in women after menopause and in men.
Tymlos is a medicine to treat osteoporosis. It helps make your bones stronger and less likely to break.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$1646.36/unit
Generic Available
No
RADIUS
Pricing data from NADAC (CMS), effective January 1, 2024. Compare all drug costs →
What it does
Tymlos treats osteoporosis in women after menopause and in men.
Common side effects
High calcium in your urine, Feeling dizzy, Feeling sick to your stomach
Key warnings
Tymlos may increase the risk of bone cancer (osteosarcoma).
The sections below are summarized in plain English from abaloparatide's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Tymlos is similar to a natural hormone in your body. It helps your body build new bone. This makes your bones stronger and less likely to break.
How to Take It
You will inject 80 mcg of Tymlos under your skin once a day. Inject it into the skin around your belly button. Use a different spot each day, but inject it around the same time each day. If you don't get enough calcium and vitamin D from food, take supplements.
This is a plain-language summary of abaloparatide's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
Tymlos is not for women who could get pregnant. It is not known if Tymlos can harm an unborn baby or pass into breast milk.
This is a plain-language summary of abaloparatide's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember that day. If you don't remember until the next day, skip the missed dose and take your next dose as usual.
This is a plain-language summary of abaloparatide's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Before first use, keep Tymlos in the refrigerator. After first use, you can keep it at room temperature for up to 30 days. Do not freeze or expose to heat.
Side Effects (from patient reports)
Based on 24,667 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for abaloparatide, by number of reports
- Headache
Headache
4,180 reports
- Feeling sick to your stomach
Feeling sick to your stomach
3,222 reports
- Feeling dizzy
Feeling dizzy
3,122 reports
- Feeling tired
Feeling tired
2,742 reports
- Increased heart rate
Increased heart rate
2,139 reports
- Joint pain
Joint pain
1,802 reports
- Feeling your heart beat fast or irregularly
Feeling your heart beat fast or irregularly
1,785 reports
- Bone pain 1,414
Bone pain
1,414 reports
- Back pain 1,289
Back pain
1,289 reports
- Pain 1,269
Pain
1,269 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for abaloparatide each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where abaloparatide sits
abaloparatide has more FDA adverse-event reports than 60% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is abaloparatide; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 24,667 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2015–2025.
Total Reports
24,667
Reports Mentioning Death
266
1.1% of reports — not proof of cause
Hospitalization Reports
1,677
Top Indication
Osteoporosis Postmenopausal
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | HEADACHE | 4,180 |
| 2 | NAUSEA | 3,222 |
| 3 | DIZZINESS | 3,122 |
| 4 | FATIGUE | 2,742 |
| 5 | HEART RATE INCREASED | 2,139 |
| 6 | ARTHRALGIA | 1,802 |
| 7 | PALPITATIONS | 1,785 |
| 8 | BONE PAIN | 1,414 |
| 9 | BACK PAIN | 1,289 |
| 10 | PAIN | 1,269 |
| 12 | INJECTION SITE BRUISING | 976 |
| 13 | PAIN IN EXTREMITY | 958 |
| 14 | PRODUCT DOSE OMISSION | 940 |
| 15 | PRODUCT QUALITY ISSUE | 914 |
| 16 | LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES | 857 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Tymlos may increase the risk of bone cancer (osteosarcoma). You should not take this medicine if you have certain conditions that increase this risk. These include Paget's disease, bone cancer, radiation treatment to your bones, or certain hereditary disorders. If you have symptoms of feeling dizzy, palpitations, tachycardia, or nausea, you should sit or lie down.
Common Questions
How long can I use Tymlos?
What if I have kidney problems?
Can Tymlos cause low blood pressure?
What should I do if I feel dizzy after taking Tymlos?
Can Tymlos cause high calcium levels?
What if I have a history of kidney stones?
How should I dispose of the Tymlos pen?
What does Tymlos look like?
What if the Tymlos solution has particles or is discolored?
What are the common side effects of abaloparatide?
What drug class is abaloparatide?
Is abaloparatide safe during pregnancy?
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What the FDA Data Shows for abaloparatide
The FDA label for abaloparatide (sold under brand names such as Tymlos) classifies it as a prescription-only medication in the PTHrP Analog class. Tymlos treats osteoporosis in women after menopause and in men. Official labeling lists 16 commonly reported side effects, including High calcium in your urine, Feeling dizzy, Feeling sick to your stomach.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 24,667 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: April 4, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages