Hydrocortisone and Theophylline Interaction
Drug interaction information between Hydrocortisone and Theophylline.
Hydrocortisone and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Hydrocortisone and Theophylline. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Hydrocortisone can interfere with how your body handles theophylline. This can result in theophylline levels becoming too high or too low to work properly.
What To Do
Your healthcare provider should check your blood levels of theophylline regularly. They may need to change your dose to keep the medicine at a safe and helpful level.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Hydrocortisone Also Interacts With
- Colestipol minor
- Dexamethasone minor
- Meperidine minor
- Methylprednisolone minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
Can I take Hydrocortisone and Theophylline together?
This is a major interaction. Your healthcare provider should check your blood levels of theophylline regularly. They may need to change your dose to keep the medicine at a safe and helpful level.
How serious is the interaction between Hydrocortisone and Theophylline?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Hydrocortisone and Theophylline interact?
Hydrocortisone can interfere with how your body handles theophylline. This can result in theophylline levels becoming too high or too low to work properly.
Understanding the Hydrocortisone and Theophylline Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Hydrocortisone belongs to the Corticosteroid class and Theophylline belongs to the Methylxanthine Bronchodilator class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Hydrocortisone can interfere with how your body handles theophylline. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Hydrocortisone has 5 total documented interactions on file in this dataset, and Theophylline has 86. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your healthcare provider should check your blood levels of theophylline regularly. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Hydrocortisone or Theophylline based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.